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Database: UniProt
Entry: A0A671XYU8_SPAAU
LinkDB: A0A671XYU8_SPAAU
Original site: A0A671XYU8_SPAAU 
ID   A0A671XYU8_SPAAU        Unreviewed;       457 AA.
AC   A0A671XYU8;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN   Name=GJC1 {ECO:0000313|Ensembl:ENSSAUP00010054081.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010054081.1, ECO:0000313|Proteomes:UP000472265};
RN   [1] {ECO:0000313|Ensembl:ENSSAUP00010054081.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC       {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU000630}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the connexin family.
CC       {ECO:0000256|RuleBase:RU000630}.
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DR   AlphaFoldDB; A0A671XYU8; -.
DR   Ensembl; ENSSAUT00010056837.1; ENSSAUP00010054081.1; ENSSAUG00010022317.1.
DR   GeneTree; ENSGT01090000260005; -.
DR   InParanoid; A0A671XYU8; -.
DR   OMA; VRWKQHR; -.
DR   OrthoDB; 4214922at2759; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; CONNEXIN; 1.
DR   PANTHER; PTHR11984:SF6; GAP JUNCTION GAMMA-1 PROTEIN; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW   ECO:0000256|RuleBase:RU000630};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000630};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..75
FT                   /note="Connexin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00037"
FT   DOMAIN          198..264
FT                   /note="Gap junction protein cysteine-rich"
FT                   /evidence="ECO:0000259|SMART:SM01089"
FT   REGION          397..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  51251 MW;  127FB5AC95FE9E59 CRC64;
     MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTGQPGC
     ENICYDAFAP LSHVRFWVFQ IILVATPSLM YLGYAVNKIA RAEEQADSGV VRGFSRRKPK
     KQYLAGRKQH RGIEEAEDDQ EEDPMIYEMA EMESDGAAKE DSGEGKRKVK VRHDGCQRIR
     EDGLMRIYVL QLLARSLLEV AFLCGQYALY GFAVPATYIC SSQPCPHNVD CFVSRPTEKT
     IFLLIMYTVS LLCLALNIWE MLHLGVGTIC EIVRSRRVQV PNDELYGLTQ GHGVLNKARL
     SGEDYSSYPF SWNAPSAPPG YNIAIKPPLV STGHHEQPLP ITDLTNAKMA CRQNHVNIAQ
     EERQQYTNNE DNLCKGGMGD APRGVLKDVR QLQNKLEADN TAYSQPTSHS NNDSKPHRER
     KHRQASKYTS SKADADRGSG SGSSSSKYGV IKGSEWI
//
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