ID A0A671YMK5_SPAAU Unreviewed; 1117 AA.
AC A0A671YMK5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSSAUP00010062534.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSSAUP00010062534.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010062534.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010062534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A671YMK5; -.
DR Ensembl; ENSSAUT00010065569.1; ENSSAUP00010062534.1; ENSSAUG00010025206.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..330
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 443..725
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 739..830
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 866..1117
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 26..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 123185 MW; 53293C3A9E186929 CRC64;
MGERFVVVPV DGGVRVAVEG VHSDAVVSDP ATDTGSSTTG GGTVDDREAG EDSVFEPQDP
DAVVPILEYN REPNKYGDGV PKENSPFINN TDIDKGNSYD GTNMALFEEE MDSNPMVSSL
LNKLANYTNL TQGAQEHEEA EEDEGPQMGT FMGVYLPCLQ NILGVILFLR LTWIVGTAGI
LESLAIVALC CSCTMLTAIS MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT
FAGSMYILGT IEILLTYIVP KAAIFVAEKK EDEVDALLNN MRVYGTCCLA LMSIVVFVGV
KYVNKLALVF LACVILSILA IYAGVIKTIF EPPDFPVCML GNRTLQNHNF DSCLKTEVIG
NLTITTKLWK LFCDGPEFNA TCNDYFNNNN VTSIQGIPGL TSGVISDNMW SVYGPLAMMV
ENKNLSSFGG SDPAQDIYMP YVVNDITTFF TLLVGIYFPS VTGIMAGSNR SGDLRDAQKS
IPIGTIMAIA TTSFIYVTCV VLFGACIEGV LLRDKFGDSV KGNLVIGTLS WPSPWVIVIG
SFFSCCGAGL QSLTGAPRLL QAIARDGIVP FLQVFGHGKA NGEPTWALLL TAGICEIGIL
IASLDAVAPI LSMFFLMCYL FVNLACAVQT LLRTPNWRPR FKYYHWALSF LGMSLCLALM
FISSWYYAIV AMAIASCIYK YIEYRGAEKE WGDGIRGLSL NAARYALIRL EEAPPHTKNW
RPQVLVLLNV DSDQGVKHPR LLSLTTQLKA GKGLTIVGNV LEGTYLTKDA EAKRAEQNIK
SSMSTEKTKG FCHVVVSSNL RDGFSHLIQS AGLGGMKHNT VLMGWPGTWS LKWIRLSSFI
HPETVRETTA AHHALLVAKN VDGFPTNQDR LGEGTIDVWW VVHDGGMLML LPFLLRQHKV
WRKCKMRIFT VAQMDDNSIQ MKKDLQMFLY HLRLDAEVEV VEMHDNDISA FTYEKTLVME
QRSQMLKQMQ LSRTEREREA QLIHDRNTAS HAAINDKAES GPEQVHMTWT KDKLFTERNR
NRECNANVAV RDLFNMKPEW ESLNQSNVRR MHTAVKLNEV VVNKSQGAHL VLLNMPGPPR
NRGGDENYME FLEVLLEGLN RVLLVRGGGR EVITIYS
//