ID   A0A671Z159_SPAAU        Unreviewed;       919 AA.
AC   A0A671Z159;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Solute carrier family 12 member 9-like {ECO:0000313|Ensembl:ENSSAUP00010068654.1};
GN   Name=LOC115572899 {ECO:0000313|Ensembl:ENSSAUP00010068654.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010068654.1, ECO:0000313|Proteomes:UP000472265};
RN   [1] {ECO:0000313|Ensembl:ENSSAUP00010068654.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A671Z159; -.
DR   Ensembl; ENSSAUT00010071845.1; ENSSAUP00010068654.1; ENSSAUG00010027202.1.
DR   GeneTree; ENSGT00940000164152; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF96; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        46..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        400..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        488..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          51..541
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          560..641
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          21..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   919 AA;  101606 MW;  62462A8EA8A98A02 CRC64;
     MSEKSPLLHY RLTNSTCSEP RDVCKHSGTK AGRGGRRSKD KPARKLGVVF GVVVPTLLSM
     FSVVVFLRIG FVVGQAGLYQ SIAMFLVAYF IITMTVLSVC AISTNGALDA GGAYYMISRA
     LGPEFGGSIG IMFFFANVCS SALYVLGLVE AVMSTFGIPE ACISQLLASL FLMYIMEVFD
     LFLNLTCLSL QVGAHIYAKA AFIVFLIVTT VLVSVFMSFF IVEPIVVILP DTSSLNSTSL
     STANYSGFQL HTLEGNLLPE YTVDYTTGAM MSFVTVFAVM FNGCTGIMAG SNMSGDLKNP
     SYSIPRGTIS AVLTTFVTYN LLSLLIASSC DRHLLQRDYS FLGDINIWPP MVTVGVYSST
     MSAAMSNLIG ASRILYALSK DNLFGGVLAL AKKTSRSGNP WASVLVSWLL IQVVLFTGKL
     NTIAGIVTIF FLLVYAAVNL ACLALEWASA PNFRPSFRCF TWHTCTLGII GCLLMMFLIN
     AIYAFSSIAF MLLLVMLIHY LGPISNWGYI SQALIFHQVR KYLLMLDVRK DHVKFWRPQV
     LLMVANPRSC TGLMTFINDL KKSGLYVLGH VKLGSLDTLP SDPLQSSYVS WLSLVDHLNI
     KSFVNLTIAD SVRQGVQNLL FITGFGGMRP NTLVLGFYDD HTPEDHLQGK ILLSSGHGMD
     DASPSMEPSE QRFPAFPSLR GTEEPKDLQE EEYVSVIADA VKMGRNVTLA RYFNHFDREE
     VLGSGRKIRG HRSKTGPFVD VWPLNLLRPD THGCVDVCSL FLLQLASVLQ ETRAWSQARL
     RLFLCVEAGC SLKKEEEKKL QVMLKELRIS AQVQMVAWDQ VVALHWQRQQ EEEEAERGDG
     IQEFPNTPPQ LADEYICAVN SLIRRHGAPQ PAVRFLYLPR PPADTSHYHA YLHHLDLLSR
     DLGPTLLIHG VTPVVTTDF
//