ID   A0A672FCY0_SALFA        Unreviewed;       333 AA.
AC   A0A672FCY0;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Erlin-1 {ECO:0000256|ARBA:ARBA00040567};
DE   AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1 {ECO:0000256|ARBA:ARBA00041391};
OS   Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC   Salariinae; Salarias.
OX   NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005004711.1, ECO:0000313|Proteomes:UP000472267};
RN   [1] {ECO:0000313|Ensembl:ENSSFAP00005004711.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family.
CC       {ECO:0000256|ARBA:ARBA00008164}.
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DR   AlphaFoldDB; A0A672FCY0; -.
DR   Ensembl; ENSSFAT00005005006.1; ENSSFAP00005004711.1; ENSSFAG00005002998.1.
DR   Proteomes; UP000472267; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   CDD; cd03406; SPFH_like_u3; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR033294; Erlin1/2.
DR   PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR   PANTHER; PTHR15351:SF2; ERLIN-1; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472267};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..333
FT                   /note="Erlin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025678658"
FT   DOMAIN          21..185
FT                   /note="Band 7"
FT                   /evidence="ECO:0000259|SMART:SM00244"
FT   REGION          305..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  37598 MW;  1CD0D665D2BAF79A CRC64;
     MPHVGAVFAA IAGVMAIMLH SSIHKIEEGH LAVYYRGGAL LTSPNGPGYH IMLPFITTYR
     SVQVKVIYLY LLFKFSCGGV MIYFDRIEVV NMLVPSAVVD IVRNYTADYD KTLIFNKIHH
     ELNQFCSVHT LQEVYIELFD IIDENLKTAL QKDLNAMAPG LTIQAVRVTK PKIPEAIRRN
     FELMEAEKTR LLITAQTQKV VEKEAETERK KAIIEAQKVA QVAEIQFQQK VMEKETEKKI
     SEIEDAAFLA REKAKADAEY YTAAKSAEAN TLKLTPEYLE LMKYQAIAAN SKIYFGQDIP
     NMFMEGSNSP PKSPRSPSLA NQADVFKVKP DRQ
//