ID A0A672G2U7_SALFA Unreviewed; 464 AA.
AC A0A672G2U7;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Serine incorporator 1 {ECO:0000256|ARBA:ARBA00040945};
DE AltName: Full=Tumor differentially expressed protein 2 {ECO:0000256|ARBA:ARBA00041691};
GN Name=serinc1 {ECO:0000313|Ensembl:ENSSFAP00005005394.1};
OS Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC Salariinae; Salarias.
OX NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005005394.1, ECO:0000313|Proteomes:UP000472267};
RN [1] {ECO:0000313|Ensembl:ENSSFAP00005005394.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Enhances the incorporation of serine into phosphatidylserine
CC and sphingolipids. {ECO:0000256|ARBA:ARBA00037552}.
CC -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000256|ARBA:ARBA00011492}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
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DR AlphaFoldDB; A0A672G2U7; -.
DR Ensembl; ENSSFAT00005005700.1; ENSSFAP00005005394.1; ENSSFAG00005001167.1.
DR Proteomes; UP000472267; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF15; SERINE INCORPORATOR 1; 1.
DR Pfam; PF03348; Serinc; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 464 AA; 51450 MW; 508AA8E39816B597 CRC64;
NNSKQKLCSS LSWRLLEKIP CLCGSAPCLL CRCCPSGNNS TVTRLIYALF LLLGVGVACI
MLMPGMEGQL KKIPGFCEGG MGSSIPGVEG HVNCDVLVGY KAVYRVCFGM AMFFLLFSLL
MIKVKSSQDP RAALHNGFWF FKFAAAAAIT IGSFFIAEGP FTMVWFYVGM AGAFCFILIQ
LVLLIDFAHS WNESWVEKME EGNSRCWYAA LLSVTTLNYL LSLVSLVLFY VYYTHSDGCT
ENKVFISINM LLCLGASVMS ILPHIQESQP RSGLLQSSLV TLYTMYLTWS AMTNEPDRKC
NPSLLSIIGL NSTAPAGQGQ VVQWWDAQGI VGLVLFLMCV LYSSIRNSST AQVNKLTLTS
DESALIEDGA HGDSLEEDGG PSRAVDNERD GVTYSYSFFH FMLFLASLYI MMTLTNWYSP
DSSYEVMTSK WPSVWVKICS SWICIALYVW TLVAPLVLVN RDFD
//
