ID A0A672H5R1_SALFA Unreviewed; 1060 AA.
AC A0A672H5R1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSSFAP00005024407.1};
GN Name=slc12a1 {ECO:0000313|Ensembl:ENSSFAP00005024407.1};
OS Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC Salariinae; Salarias.
OX NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005024407.1, ECO:0000313|Proteomes:UP000472267};
RN [1] {ECO:0000313|Ensembl:ENSSFAP00005024407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A672H5R1; -.
DR Ensembl; ENSSFAT00005025387.1; ENSSFAP00005024407.1; ENSSFAG00005012543.1.
DR InParanoid; A0A672H5R1; -.
DR OMA; FRIKFAE; -.
DR Proteomes; UP000472267; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472267};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 146..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..100
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 142..646
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 655..1046
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 116771 MW; 4DBAD7A5A0857FE2 CRC64;
MERFRSSRGE HVNPAYDANL DEPPVYQEPN ESRIIRPSVV SAFGHDTLDR VPNIDFYRNA
GSVSGHRAVR PSLQELHDVF QKNGAISVLD TVKDDDEESE DAPSDDVESA APMPSDKGSV
KFGWIRGVMV RDFGSHETVS FLQVRCMLNI WGVILFIRLS WVFGQTGWGL GIVVIALSCV
VTTITGLSMS AICTNGVVRG GGAYYLISRS LGPEFGGSIG LIFAFANAVA VAMYVVGFAE
TVVELLLEYD SIMVDPLNDI RIISCITVVV LLGISVAGME WEAKAQIVLL VILLAAIVNV
FAGTFMPADD TRKSQGFFGY SAEIFLENFA PDFRGSESFF SVFAIFFPAA TGILAGANIS
GDLRDPQSAI PKGTLLAIVI TGITYLAVAL CVSASVVRDA TGNVTDAIIS PIFCNGSAAA
ACELGFDFSS CAEKPCAYGL MNNFQVMSMV SAFDPLIIAG TFSATLSSAL ASLVSAPKVF
QALCQDNIYK ILHFFAKGYG KNNEPIRGYI LTFIISVAFI LIGDLNAIAP IISNFFLASY
ALINFSCFHA SYAKSPGWRP AYKYYNMWLS LLGALLCCAV MFVINWWAAL ITYAIEILLY
IYVTVKKPDV NWGSSTQAVT FVSAVGNALS LSGVEDHVKN FRPQMLVLTG SARARPALLD
LAQSFSKTFG LCITAEVFVG ARSEALQEMN AAMEKNQLWL RKTKRKAFYA AVACDEFRDG
ADSLLQASGL GRMKPNTLMI GFKKNWRTAG TDSVQSYVGI LHDAFDLEYG TVILRISEGL
DMSHIVEEEE EMMRAAKEQR ELEKETMPNG GKPKGLFRKS RNSSQQVLTT RVSVCGPPPA
QVAKMNERLT EAGHQFKKKQ PKGTIDVWWL FDDGGLTLLL PYILTTRKKW KDSKLRIFIA
GQPGRSELDK EEMKSLLQKF RINCSDITVV DDIHVPPRSE SSRKFEEMIE PFRLREGSGD
SVQAAAMRKQ NPWKITDEEL SSFEEKTNLQ IRLNELLQEH SKLATLIVVS MPIARKESIS
DFLYMAWLDI LTKDLPPTLL MRGNHKINVH SRHMTSIQVP
//
