ID A0A672HCK9_SALFA Unreviewed; 986 AA.
AC A0A672HCK9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Insulin degrading enzyme {ECO:0000313|Ensembl:ENSSFAP00005026725.1};
GN Name=ide {ECO:0000313|Ensembl:ENSSFAP00005026725.1};
OS Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC Salariinae; Salarias.
OX NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005026725.1, ECO:0000313|Proteomes:UP000472267};
RN [1] {ECO:0000313|Ensembl:ENSSFAP00005026725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR AlphaFoldDB; A0A672HCK9; -.
DR Ensembl; ENSSFAT00005027763.1; ENSSFAP00005026725.1; ENSSFAG00005009802.1.
DR Proteomes; UP000472267; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000472267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 60..195
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 229..383
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 389..670
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 674..856
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 986 AA; 113397 MW; CD3F9AD59CBF8961 CRC64;
MEPDGSGGGA DCPPISRLVS SLPLRMTDPA VNRVVSDIIR SPEDKREYRG LEFTNGLKAM
LISDPTTDKS SAALDVHIGS LSDPSNISGL AHFCEHMLFL GTQKYPKENE YSQFLSEHAG
SSNAFTSGEH TNYYFDVSHE HLQGALDRFA QFFLCPLFDE SCKDREVNAV DSEHEKNLMN
DAWRLFQLEK ATGNPNHPFS KFGTGSNPDS LSDTESNGEC FLLCVLFAES LDELTSMVVK
LFGEVENKNV PIPEFPEHPF QEEHLKQFYK VVPIKDIRNL YVTFPIPDLQ KYYKSNPGHY
LGHLIGHEGP GSLLSELKSK GWVNTLVGGQ KEGARGFMFF IINVDLTEEG LLHVEDIIFH
MFQYIQKLRT EGPQEWVFDE CKDLNKVAFR FKDKERPRGY TSKVAGLLHY YPLEEVLAAE
YLLEDFRPDL IEMVLDKLRP EQVRVAVVSK SFEGKTDKTE EWYGTQYSQE AISEETIQNW
ANADLNGKFK LPMKNEFIPT NFEIYPLEKD APAVPSLIKD TAMSKVWFKQ DDKFFLPKAC
LNFEFFSPFA YVDPLHCNMA YLYLELLKDS LNEYAYAAEL AGLNYDLQNT IYGMYLSVKG
YNDKQHILLK KIIEKMATFE IDEKRFDIIK EAYMRSLNNF RAEQPHQHAM YYLRLLMTEV
AWTKDELREA LDDVSLPRLK AFIPQLLSRL HIEALLHGNI TKESALGMMQ MVEDTLIEHA
HTKPLLPSQL IRYREVQVPD GGWYVYQQRN EVHNNCGIEI YYQTDMQTTH DNMLLELFCQ
IISEPCFNTL RTKEQLGYIV FSGPRRANGV QGLRFIIQSE KAPHYLESRV EAFLCTMEKA
VEDMSEEAFQ KHIQALAIRR LDKPKKLSAE CAKYWGEIIS QQYNFDRDNI EVAYLKTLSK
ENIMQFYRER LTIEAPKRHK VSVHVLSREM DSCPVVGEFP AQNDVNLAPA PSLPQPTLVQ
DMTEFKRSLP LFPLVKPHIN FMAAKL
//
