ID   A0A672IN69_SALFA        Unreviewed;       974 AA.
AC   A0A672IN69;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Ubiquitin like modifier activating enzyme 6 {ECO:0000313|Ensembl:ENSSFAP00005042497.1};
OS   Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC   Salariinae; Salarias.
OX   NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005042497.1, ECO:0000313|Proteomes:UP000472267};
RN   [1] {ECO:0000313|Ensembl:ENSSFAP00005042497.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC       {ECO:0000256|ARBA:ARBA00005673}.
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DR   AlphaFoldDB; A0A672IN69; -.
DR   Ensembl; ENSSFAT00005044035.1; ENSSFAP00005042497.1; ENSSFAG00005021046.1.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000472267; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR   Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR   Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR   Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR   InterPro; IPR032420; E1_4HB.
DR   InterPro; IPR032418; E1_FCCH.
DR   InterPro; IPR042302; E1_FCCH_sf.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR018965; Ub-activating_enz_E1_C.
DR   InterPro; IPR038252; UBA_E1_C_sf.
DR   InterPro; IPR019572; UBA_E1_SCCH.
DR   InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   InterPro; IPR018075; UBQ-activ_enz_E1.
DR   InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR   NCBIfam; TIGR01408; Ube1; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PANTHER; PTHR10953:SF186; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6; 1.
DR   Pfam; PF16191; E1_4HB; 1.
DR   Pfam; PF16190; E1_FCCH; 1.
DR   Pfam; PF09358; E1_UFD; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   Pfam; PF10585; UBA_E1_SCCH; 1.
DR   PRINTS; PR01849; UBIQUITINACT.
DR   SMART; SM00985; UBA_e1_C; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472267}.
FT   DOMAIN          841..963
FT                   /note="Ubiquitin-activating enzyme E1 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00985"
SQ   SEQUENCE   974 AA;  108941 MW;  6A7F0204400CE9E9 CRC64;
     MAADSMEIDD SLYSRQRYVL GDRAMHQMAQ SSVFLSGMGG LGIEIGWEIA TFCFVNLLLL
     YHQFIIFNLN PYVHVDISSS ALDDNTDLSF LRKYQCVILT EARLNLQKRV NDFCHSQQPP
     IRFIGCDAYG ICVRVFCDFG DEFEVSDPTG EEPKEIFIQN ITQDNPGVVT CMDNQPHGLQ
     TGQSVIFREV GGMVELNGTT QQVSVLSPHS FAIRDTSLLQ PYAHGGFFVL VKTPKTYRFE
     TLEQQLCDPQ VLIPDFSKPE APLQIHAAML ALETFQEQHS RLPNVGCLQD ADVLLKLTEE
     APVNTELVHC LSRTARGTLP PLAAAVGGVA SQEVLKAITG KFAPLQQWLY LDAVEVVRPL
     QALATEEFFP RGDRYDGLRA CIGESMCLEL HKLRVFMVGC GAIGCEMLKN FALLGVGLAK
     SSGEVSIVLF SSAVSLQTTS YSAAEATCEI NPDLQVEAHL NKVCPATENI YNDSFYSSLN
     LVVTALDNVE ARRYVDSRCV SNQRPLLDSG TMGTKGHTEI IVPNLTESYN SHRDPPEEEI
     PFCTLKSFPS VIEHTIQWAR DKFENAFVHK PSLYNSFWQT HSSAEVVLQR MQTGESLEGS
     FQVIKLLSRR PSRWEQCITV ARLKFEKYFK RKALQLLHSF PLDTRLKDGS LFWQSPKRPP
     TPIEFDLKDS LHFTFIVSTA RLFAGIYNIS YTEKDLSEET VARILATVKI PQYSPSEKCI
     ETDESAKKPD QMKMPVSSEE EREAIVQLEE AIATDRVTPE GLQMSPLQFE KDDDSNGHMD
     FVTSASALRA TMYSIEPADR LKTKRIAGKI IPAIATATAA VAGLVALELI KVVGGYEFES
     FKNCFFNLAI PVIVLTEPAI VKRTLIRNNI YFSIWDCWTI FGHEDFTLSE FMNAVREKYG
     IEPTMVVHGV KMLYVPVMPG HSKRLKLTMQ KLIKPSVDRR YVDLTVSFAP EADGDEDLPG
     PPVRYYFSPG AGTP
//