ID A0A672J8Z2_SALFA Unreviewed; 854 AA.
AC A0A672J8Z2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 2 {ECO:0000313|Ensembl:ENSSFAP00005050678.1};
GN Name=scube2 {ECO:0000313|Ensembl:ENSSFAP00005050678.1};
OS Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC Salariinae; Salarias.
OX NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005050678.1, ECO:0000313|Proteomes:UP000472267};
RN [1] {ECO:0000313|Ensembl:ENSSFAP00005050678.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A672J8Z2; -.
DR Ensembl; ENSSFAT00005052319.1; ENSSFAP00005050678.1; ENSSFAG00005024351.1.
DR Proteomes; UP000472267; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000472267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..854
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025535258"
FT DOMAIN 28..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 306..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 347..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 666..778
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 351..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 854 AA; 94990 MW; 9A12617C18D5233C CRC64;
MGAARAARDV CLFLLLLNSR QSAALPEIRD PCAEGSDGCH IDAICQTTQG SYKCTCKAGF
KGDGKHCEDI DECDLEYNGG CVHECNNIPG NYRCTCYDGF NLAHDGHNCL DVDECKFNNG
GCQHTCVNTM GSYECRCKEG FFLSDNQHTC IHRSVEGLNC MNKEHGCAHI CKETHRGGVA
CECRPGFLLA RNQRGCILTC NHGNGGCQHT CEDTESGPIC RCHVRYSLQP DKRSCLERDE
ATGESSDHNA TSFTEVDKRV KRRLLMETCA VNNGGCDCTC KDTSTGVRCS CPVGFTLQPD
GKTCKDIDEC ELHNGGCEHF CRNTIGSFEC NCRKGFKLLT DERSCQDIDE CFFERTCDHT
CVNSPGGFQC LCNKGYTMYG LAHCGDINEC SVNNGGCEQG CENTMGGFEC FCRPGFKLHW
NKKDCIAESC DLSCVRRRSE KRLRKTIRTL RKSINREQFH LHFAGADYEL SKSLGQPAEL
PGHCVAGQVL IGRKCVSCGV GTYFDGDQGR CVVCPAGTYQ DEEGQMSCEV CPGPEGRDVS
KVVGARNMSE CGGQCSPGQY SRDGFVPCLF CPLGTYQPEV GRTSCFTCGG NLVTKHSGAV
SFQECETKVQ CSPGHYYNTS THRCIRCPTG TYQGEFGQNY CVACPGNTTT DFDGSTSIMQ
CKNRQCGGEL GDFTGYIESP NYPGNYPANI ECTWTINPPP KRRILIVVPE IYLPIEDECG
DYLVMRKSSL SNSVTTYETC QTYERPIAFT SRSKRLWIQF RSNEGNSGKG FQVPYVTYDE
DYQELIEDIV RDGRLYASEN HQEILKDKKL MKALFDVLAH PQNFFNYTAQ ESREMFPKSF
IRFLRSKVLR FLRP
//