ID A0A672JH99_SALFA Unreviewed; 1053 AA.
AC A0A672JH99;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 2-like {ECO:0000313|Ensembl:ENSSFAP00005052410.1};
GN Name=LOC115381479 {ECO:0000313|Ensembl:ENSSFAP00005052410.1};
OS Salarias fasciatus (Jewelled blenny) (Blennius fasciatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Blenniimorphae; Blenniiformes; Blennioidei; Blenniidae;
OC Salariinae; Salarias.
OX NCBI_TaxID=181472 {ECO:0000313|Ensembl:ENSSFAP00005052410.1, ECO:0000313|Proteomes:UP000472267};
RN [1] {ECO:0000313|Ensembl:ENSSFAP00005052410.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A672JH99; -.
DR Ensembl; ENSSFAT00005054071.1; ENSSFAP00005052410.1; ENSSFAG00005024964.1.
DR Proteomes; UP000472267; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472267}.
FT DOMAIN 51..331
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 542..733
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 762..859
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 936..1033
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 420..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 644..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 420..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 120667 MW; 3E4953F865B1048E CRC64;
MGEIEGSYRV LQTPGTRLGA QFNAGISTLE PGQSLGGNNM VSGGRNYGRE LQIRVQGLDD
SQEFFDIDCK ALGQALLAEV FHRGNLMESD YFGLEFQNMQ LNWVWLEPTK PVAKQVRRPA
NTLFRLSVKF FPPDPGQLQE EYTRYLFSLQ IKRDLMEGRL VCSENTGALL ASHLVQSEIG
DYDDAADRDY LRTNKLLPYQ EKVQERIMEL HRRHLGQTPA ESDFQILEIA RKLELYGVRF
HPAADREGTK INLAVAHMGL QVFQANTKIN TFNWSKIRKL SFKRKRFLIK LHPEVHGPHQ
DTLEFLMGSR DQCKIFWKIC VEYHSFFRLF DQPQPKSKAI LFTRGSSFRY SGRTQKQLVD
YVKENGAKRT PYQRLFSFVF VLLSCFQSLS FNDSLRAPGS PSSTVSFHSA HISNILPRTE
LKPQPQPLST VSPSPPSLQQ QQQLQSPLQA TTRPPTPPKE EPVQATSPFP GALSNTVVDS
PQLSPFTSKE PLCLSPSFQM STLSLPGQAP SPLQSPILSE VGSNVHCQQS PPIHKPKNHT
THSYFIAKEI LTTERTYLKD LEVITVWFRS AVIKENAMPE GLMTLLFSNI DPIYEFHRGF
LKELDQRLAL WWGRSNAHVK GDYQRIGDVM LKNMCALKEF TSYLQKHDEV LTELEKASKR
LKKLETVYKE FELQKVCYLP LNTFLLKPIQ RLMHYKLILE RLCKHYSPSH RDHDDCKEAL
KEVADIAAQL QSSLIRLENF QKLTELQRDL IGIENLTAPG REFIREGCLY KLTKKGLQQR
MFFLFSDMLL YTSKGVTATN QFKVHGQLPL HGMIVEESEN EWSVPHCFTI YSAQRTIVVA
ASSKVEMGKW IEDLNLAIDM AKKSQEKSSI FLDAGLNDHS NRSSDEVSLE QESEDDMNSS
RTSLDKQTHH RANTTMHVCW HRNTSVSMSD HSLAVENQLS GYLLRKFKNS NGWQKLWVVF
TNFCLFFYKT HQDDFPLASL PLLGYSVSTP EESDNIHKEY VFKLQFKSHV YFFRAESEYT
FERWMEVIKS AASTTGRMSL LIPKGGPMEM NGN
//
