ID A0A672THK6_STRHB Unreviewed; 1140 AA.
AC A0A672THK6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSSHBP00005000648.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSSHBP00005000648.1};
OS Strigops habroptila (Kakapo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Strigops.
OX NCBI_TaxID=2489341 {ECO:0000313|Ensembl:ENSSHBP00005000648.1, ECO:0000313|Proteomes:UP000472266};
RN [1] {ECO:0000313|Ensembl:ENSSHBP00005000648.1, ECO:0000313|Proteomes:UP000472266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jarvis E.D., Howard J., Rhie A., Phillippy A., Korlach J., Digby A.,
RA Iorns D., Eason D., Robertson B., Raemaekers T., Howe K., Lewin H.,
RA Damas J., Hastie A., Tracey A., Chow W., Fedrigo O.;
RT "Strigops habroptila (kakapo) genome, bStrHab1, primary haplotype, v2.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSHBP00005000648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A672THK6; -.
DR Ensembl; ENSSHBT00005000806.1; ENSSHBP00005000648.1; ENSSHBG00005000398.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000472266; Chromosome 3.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472266};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..195
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 263..764
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 773..907
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 929..1140
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 125353 MW; 7DCB6EB23A2AECE8 CRC64;
MEGKQQLPPA GPAVLGAASD ERRSEDSKDG AGGGALGRPL GPTPSQSRFQ VDLVAEGAGR
PAEELRKASG EGSAAGKGSE EAKGRFRVNF VDPSAGDESP GEPGGGSSEG GNVSFQNGGD
TVMSEGSLHS GGHHHHYYYD THTNTYYLRT FGHNTMDAVP RIDYYRHTAA DLGEKLIRPS
LAELHDELDK VSCLECSCQK KRHCDLPEEW NQGRKEGVPV QRWFVEPFED GYANGDEGTP
AGEATASYTP DSKGVVKFGW IKGVLVRCML NIWGVMLFIR LSWIVGQAGI GLSVVVIGMA
TVVTTITGLS TSAIATNGFV RGGGAYYLIS RSLGPEFGGA IGLIFAFANA VAVAMYVVGF
AETVVELLKE NGALMVDEMN DIRIIGAITV VILLGISVAG MEWESKAQIV LLVILILAIG
DFVIGTFIPL DSKKPKGFFG YKAEIFMENF GPDFRHEETF FSVFAIFFPA ATGILAGANI
SGDLADPQSA IPKGTLLAIL ITTLVYVGIA VSVGSCVVRD ATGNVNDTIV TELMNCTAAA
CKLNYDFSSC QTECPYGLMN NFQVMSMVSG FAPLISAGIF SATLSSALAS LVSAPKIFQA
LCKDNIYPGF QMFAKGYGKN NEPLRGYLLT FLIALGFILI AELNVIAPII SNFFLASYAL
INFSVFHASL AKSPGWRPAF KYYNMWISLL GAILCCIVMF VINWWAALLT YVIVLGLYIY
VTYKKPDVNW GSSTQALTYL NALQHSIRLS GVEDHVKNFR PQCLIMTGVP SARPALLHLV
HAFTKNVGLM ICGHVHMGPR RQAMKELSAD LAKYQRWLIK NKMKAFYAPV HAEDLRDGGQ
YLMQAAGLGR MRPNTLVVGF KKNWRQSDMR DVETYINLFH DAFDIQYGVV VIRLKEGLDI
SHLQGQAKCL TSILSYFFFP DSKSQSSPLN LTDQRLLDAS TQFQKKQGKS NIDVWWLFDD
GGLTLLIPYL LTTKKKWKDC RIRVFIGGKI NRIDHDRRAM ATLLSKFRID FSDIMVLGDI
NTKPKKENIA AFEEMIEPFR LHEDDKEQEV ADKMKEDEPW RITDNELELY KTKTYRQIRL
NELLQEHSST ANIIVMSLPV ARKGAVSSAL YMAWLEALSK DLPPILLVRG NHQSVLTFYS
//
