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Database: UniProt
Entry: A0A672UFB3_STRHB
LinkDB: A0A672UFB3_STRHB
Original site: A0A672UFB3_STRHB 
ID   A0A672UFB3_STRHB        Unreviewed;       921 AA.
AC   A0A672UFB3;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146};
DE            EC=7.2.2.10 {ECO:0000256|RuleBase:RU361146};
GN   Name=ATP2C2 {ECO:0000313|Ensembl:ENSSHBP00005013808.1};
OS   Strigops habroptila (Kakapo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Strigops.
OX   NCBI_TaxID=2489341 {ECO:0000313|Ensembl:ENSSHBP00005013808.1, ECO:0000313|Proteomes:UP000472266};
RN   [1] {ECO:0000313|Ensembl:ENSSHBP00005013808.1, ECO:0000313|Proteomes:UP000472266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jarvis E.D., Howard J., Rhie A., Phillippy A., Korlach J., Digby A.,
RA   Iorns D., Eason D., Robertson B., Raemaekers T., Howe K., Lewin H.,
RA   Damas J., Hastie A., Tracey A., Chow W., Fedrigo O.;
RT   "Strigops habroptila (kakapo) genome, bStrHab1, primary haplotype, v2.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSHBP00005013808.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of
CC       calcium. {ECO:0000256|RuleBase:RU361146}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate;
CC         Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.2.2.10;
CC         Evidence={ECO:0000256|RuleBase:RU361146};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate;
CC         Xref=Rhea:RHEA:66820, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29035, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024272};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66821;
CC         Evidence={ECO:0000256|ARBA:ARBA00024272};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361146}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU361146}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IIA subfamily. {ECO:0000256|ARBA:ARBA00005675,
CC       ECO:0000256|RuleBase:RU361146}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361146}.
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DR   AlphaFoldDB; A0A672UFB3; -.
DR   Ensembl; ENSSHBT00005016582.1; ENSSHBP00005013808.1; ENSSHBG00005012019.1.
DR   GeneTree; ENSGT00940000160275; -.
DR   Proteomes; UP000472266; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006413; P-type_ATPase_IIA_PMR1.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01522; ATPase-IIA2_Ca; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR   PANTHER; PTHR42861:SF23; CALCIUM-TRANSPORTING ATPASE TYPE 2C MEMBER 2; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00120; HATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361146};
KW   Calcium {ECO:0000256|RuleBase:RU361146};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU361146};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361146};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361146};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361146};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472266};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361146};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361146}; Transport {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        275..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        298..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        783..803
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        815..832
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        852..869
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        881..899
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   DOMAIN          54..103
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00690"
FT   DOMAIN          734..905
FT                   /note="Cation-transporting P-type ATPase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00689"
SQ   SEQUENCE   921 AA;  100844 MW;  8FDF1217C008BC67 CRC64;
     ADEPDLSVFF SKHPGGAGSR CQIPPTHEEC ELKIIEQEKE VAVLPPKDAC KFHKEDLAKA
     LNVNLQTGLS ECSVLQRRLK HGWNEFSVEN TEPIWKKYLD QVRIFCTDSH FLAKTPVWIS
     LSVSLHQSIQ ALLCNFLVSI LLFPFVSCSL REGKLQHLLA RELVPGDIIY LSVGDRVPAD
     LRLIEVTDLL VDESSFTGEA EPCNKTDSVL LEAGDITTLS NVVFMGTLVR CGKGKGVVIG
     TGENSQFGEV FKMMQAEETP KTPLQKSMDR LGKQLTLFSF GIIGLIMLIG WLQGKHLLGM
     FTIGVSLAVA AIPEGLPIVV TVTLVLGVLR MAKKRVIVKK LPIVETLGCC NVICSDKTGT
     LTANEMTVTR LVTSDGFQAE VSGVGYNGEG KVYLLPSKEI LKEFSNVSVG KLVEAGCVVN
     NAIIRKNSVM GQPTEGALIA LAMKMELADI KDIYVRNKEI PFSSEQKWMA VKCTLKNQDQ
     DDIYFMKGAF EEVIRHCSLY NSGGISLSLT PQQKAFYQQE EKRMGSSGLR VLALASGPEL
     GKLTFLGLVG IIDPPRAGVR EAVQVLLESG VSVKMITGDA LETAVAIGRQ NIGLCNGKLK
     AMSGEELDQL AETELSSTVK NVSIFFRTSP KHKLKIIKAL QRAGAIVSMT GDGVNDAVAL
     KSADIGIAMG QAGTDVSKEA ANMILVDDDF STVMNAIEEG KGIFYNIKNF VRFQLSTSIS
     ALSLITLSTV LNLPNPLNAM QILWINIIMD GPPAQSLGVE PVDRDTIKQP PRRITDTILS
     KSLILKIFMS AVIIISGTLF VFWKENPKGG ITPRTTTMTF TCFVFFDLFN ALTCRSQTKL
     IFEIGFFRNR MFLYSVLGSF LGQLAVIYIP PLQKIFQTEN LGVLDLLFLT VLASSVFIVS
     EFVKLCEKQC CQPKHTKGCH N
//
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