ID A0A672UHM1_STRHB Unreviewed; 919 AA.
AC A0A672UHM1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 1 {ECO:0000313|Ensembl:ENSSHBP00005014701.1};
GN Name=SCUBE1 {ECO:0000313|Ensembl:ENSSHBP00005014701.1};
OS Strigops habroptila (Kakapo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Strigops.
OX NCBI_TaxID=2489341 {ECO:0000313|Ensembl:ENSSHBP00005014701.1, ECO:0000313|Proteomes:UP000472266};
RN [1] {ECO:0000313|Ensembl:ENSSHBP00005014701.1, ECO:0000313|Proteomes:UP000472266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jarvis E.D., Howard J., Rhie A., Phillippy A., Korlach J., Digby A.,
RA Iorns D., Eason D., Robertson B., Raemaekers T., Howe K., Lewin H.,
RA Damas J., Hastie A., Tracey A., Chow W., Fedrigo O.;
RT "Strigops habroptila (kakapo) genome, bStrHab1, primary haplotype, v2.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSHBP00005014701.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A672UHM1; -.
DR Ensembl; ENSSHBT00005017657.1; ENSSHBP00005014701.1; ENSSHBG00005006884.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000472266; Chromosome 4.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR PRINTS; PR00907; THRMBOMODULN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000472266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 35..75
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 119..155
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 284..324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 325..363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 729..841
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 329..339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 919 AA; 102231 MW; 08CC36C7AB0F12A1 CRC64;
MFTSLTFPRL PNLDSHSSPI SLLICPLGVP SVLPDVDECA EATDDCHIDA ICQNTPKSYK
CICKPGYKGE GKQCEDIDEC ENDFYNGGCV HECINIPGNY RCTCYDGFML AHDGHNCLDV
DECQDNNGGC QQICVNTMGS YECQCKEGFF LSDNQHTCIH RSIEGMNCMN KDHGCAHICR
ETPKGGVACE CRPGFELAKN QKDCKLTCNY GNGGCQHTCD DTDTGPVCGC HQKYALHSDG
RTCIETCAVN NGGCDRTCKD TATGVRCSCP VGFTLQPDGK TCKDIDECLV NNGGCDHFCR
NTVGSFECSC QKGYKLLTDE RTCQDIDECS FERTCDHTCI NYPGSFECLC HKGYTLYGLT
HCGDIDECSI SNGSCDYGCL NTMGSYECVC PPGKKLHWNK KDCLFYFMST DSLAPPIKQK
ARFKIKDAKC HLRPRSKEKT KDSGKQADNC QVTFVNLKCD SSKKKRRGRK SPSKEVSHIT
AEFEVEMKSE EVSDTCNIDC VRKRMEQKLQ TAIKTLRKSI NKQQFYIQFS GTEYEVAQKP
AKATEGHEAC STGQVLQDGK CVTCSTGTFY SGEHNQCVPC SPGTYQDTEG QLTCEPCPSN
DGQGVAGARN VSECGGQCSP GHYSSDGFKP CRVCPLGTYQ PEPGRTLCFP CGGGLVTKYE
GAVSFQDCET KVHCSPGHYY NSTTHRCIRC PVGTYQPEFG QNYCITCPGN TSTDFDGSTN
VTHCKNQHCG GELGDYTGYI ESPNYPGDYP ANVECIWNIN PPPKRRILIV VPEIFLPIED
ECGDVLVMRK SASPTSITTY ETCQTYERPI AFTSRSRKLW IQFKSNEGNS GKGFQVPYVT
YDEDYQQLIE DIVRDGRLYA SENHQEILKD KKLIKALFDV LAHPQNYFKY TAQESKEMFP
RSFIKLLRSK VSRFLRPYK
//
