ID A0A672UJE0_STRHB Unreviewed; 949 AA.
AC A0A672UJE0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 1 {ECO:0000313|Ensembl:ENSSHBP00005014522.1};
GN Name=SCUBE1 {ECO:0000313|Ensembl:ENSSHBP00005014522.1};
OS Strigops habroptila (Kakapo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Strigops.
OX NCBI_TaxID=2489341 {ECO:0000313|Ensembl:ENSSHBP00005014522.1, ECO:0000313|Proteomes:UP000472266};
RN [1] {ECO:0000313|Ensembl:ENSSHBP00005014522.1, ECO:0000313|Proteomes:UP000472266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jarvis E.D., Howard J., Rhie A., Phillippy A., Korlach J., Digby A.,
RA Iorns D., Eason D., Robertson B., Raemaekers T., Howe K., Lewin H.,
RA Damas J., Hastie A., Tracey A., Chow W., Fedrigo O.;
RT "Strigops habroptila (kakapo) genome, bStrHab1, primary haplotype, v2.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSHBP00005014522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A672UJE0; -.
DR Ensembl; ENSSHBT00005017445.1; ENSSHBP00005014522.1; ENSSHBG00005006884.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000472266; Chromosome 4.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR PRINTS; PR00907; THRMBOMODULN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000472266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 7..47
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 91..127
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 256..296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 759..871
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 301..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 949 AA; 105219 MW; AD896D9D426E76CE CRC64;
AGPARQDVDE CAEATDDCHI DAICQNTPKS YKCICKPGYK GEGKQCEDID ECENDFYNGG
CVHECINIPG NYRCTCYDGF MLAHDGHNCL DVDECQDNNG GCQQICVNTM GSYECQCKEG
FFLSDNQHTC IHRSIEGMNC MNKDHGCAHI CRETPKGGVA CECRPGFELA KNQKDCKLTC
NYGNGGCQHT CDDTDTGPVC GCHQKYALHS DGRTCIETCA VNNGGCDRTC KDTATGVRCS
CPVGFTLQPD GKTCKDIDEC LVNNGGCDHF CRNTVGSFEC SCQKGYKLLT DERTCQDIDE
CSFERTCDHT CINYPGSFEC LCHKGYTLYG LTHCGDIDEC SISNGSCDYG CLNTMGSYEC
VCPPGKKLHW NKKDCVEMVK CLPNAKPAPK AQLVCSKTGG IESCFLSCPS NTLFVPDSEN
SYTLSCGVPV QQGKAQQKRN ATLPSYSLAP PIKQKARFKI KDAKCHLRPR RGQFPCTDNC
QVTFVNLKCD SSKKKRRGRK SPSKEVSHIT AEFEVEMKSE EVSDTCNIDC VRKRMEQKLQ
TAIKTLRKSI NKQQFYIQFS GTEYEVAQKP AKATEGHEAC STGQVLQDGK CVTCSTGTFY
SGEHNQCVPC SPGTYQDTEG QLTCEPCPSN DGQGVAGARN VSECGGQCSP GHYSSDGFKP
CRVCPLGTYQ PEPGRTLCFP CGGGLVTKYE GAVSFQDCET KVHCSPGHYY NSTTHRCIRC
PVGTYQPEFG QNYCITCPGN TSTDFDGSTN VTHCKNQHCG GELGDYTGYI ESPNYPGDYP
ANVECIWNIN PPPKRRILIV VPEIFLPIED ECGDVLVMRK SASPTSITTY ETCQTYERPI
AFTSRSRKLW IQFKSNEGNS GKGFQVPYVT YDEDYQQLIE DIVRDGRLYA SENHQEILKD
KKLIKALFDV LAHPQNYFKY TAQESKEMFP RSFIKLLRSK VSRFLRPYK
//
