ID A0A672VA53_STRHB Unreviewed; 347 AA.
AC A0A672VA53;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Erlin-1 {ECO:0000256|ARBA:ARBA00040567};
DE AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1 {ECO:0000256|ARBA:ARBA00041391};
GN Name=ERLIN1 {ECO:0000313|Ensembl:ENSSHBP00005024349.1};
OS Strigops habroptila (Kakapo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Strigops.
OX NCBI_TaxID=2489341 {ECO:0000313|Ensembl:ENSSHBP00005024349.1, ECO:0000313|Proteomes:UP000472266};
RN [1] {ECO:0000313|Ensembl:ENSSHBP00005024349.1, ECO:0000313|Proteomes:UP000472266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jarvis E.D., Howard J., Rhie A., Phillippy A., Korlach J., Digby A.,
RA Iorns D., Eason D., Robertson B., Raemaekers T., Howe K., Lewin H.,
RA Damas J., Hastie A., Tracey A., Chow W., Fedrigo O.;
RT "Strigops habroptila (kakapo) genome, bStrHab1, primary haplotype, v2.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSHBP00005024349.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family.
CC {ECO:0000256|ARBA:ARBA00008164}.
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DR AlphaFoldDB; A0A672VA53; -.
DR Ensembl; ENSSHBT00005028969.1; ENSSHBP00005024349.1; ENSSHBG00005020279.1.
DR GeneTree; ENSGT00390000014666; -.
DR OrthoDB; 3129813at2759; -.
DR Proteomes; UP000472266; Chromosome 6.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR CDD; cd03406; SPFH_like_u3; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR033294; Erlin1/2.
DR PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR PANTHER; PTHR15351:SF2; ERLIN-1; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000472266};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 23..189
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT REGION 319..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 38983 MW; ACA008C08F6B448F CRC64;
MTMAQAGAVV AAATGLLVFF LYSSIHKVEE GHLAVYYRGG ALLTSPSGPG YHIMLPFITT
FKSVQTTLQT DEVKNVPCGT SGGVMIYIDR IEVVNKLAPY AVYDIVRNYT ADYDKTLIFN
KIHHELNQFC SAHTLQEVYI QLFDQIDENL KLALQKDLNV MAPGLTIQAV RVTKPKIPEA
IRRNFELMEA EKTKLLIAAQ KQKVVEKEAE TDRKKALIEA EKAAQVAKIH YQQKIMEKET
EKRISEIEDA AFLAREKAKA DAEFYAAWKL ADSNKLKLTP EYLELMKYEA IAANSKLYFG
DRIPNVFLDS CAFQQPNLRT AQETNLPSQE APETSGENHL RAKESTG
//
