ID A0A672Z4X4_9TELE Unreviewed; 707 AA.
AC A0A672Z4X4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 4 {ECO:0000313|Ensembl:ENSSORP00005011522.1};
GN Name=hsd17b4 {ECO:0000313|Ensembl:ENSSORP00005011522.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005011522.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005011522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; A0A672Z4X4; -.
DR Ensembl; ENSSORT00005011906.1; ENSSORP00005011522.1; ENSSORG00005004604.1.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271}.
FT DOMAIN 470..568
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 601..702
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 707 AA; 76629 MW; A9B33287E047DECA CRC64;
MSLSFEGRVV LVTGAGGGLG KEYALAFAER GASVVVNDLG VDTKGGGKSS AAADKVVEEI
RAKGGKAVAN YDSVEDGEKL IQTALDEFGR IGKLQCFFCI NIYFSFILLS TPDLIHRVHL
RGSFLVTRAA WNHMKKQKFG RIIMTASAAG IYGNFGQANY SAAKLGMLGL ANTLAIEGRN
YNIYCNTIAP VAGSRLTETV MPPDLVASLK PEYVAPIVLW LCHEQCQENG GLFEVGAGWI
GKLRWERSQG CIVRSKNEPM SPEAVRDQWE KICDFTDSTR PLNIGESLQS MVSVLSRVDG
GVGANPTASA AEAVGQKLPP TTFSFNHTQS ILYALGVGMS TKDSDHLRFL YEGHPDFSCL
PTFGVIPSQA AMMDGGLGSV PGLNIDFTQV LHGEQYLELY KPLPTSGIQL FLSKPPCLFL
LAVNTYSGKE LVCYNQWSVF VVGAGGFGGK RNSDKAKVCV VSKQCVVSLR IQAALYRLSG
DWNPLHIDPS FAAMGGFKAP ILHGLCSFGF AARHVLKQYA DNDPSRFKAI KVRFVKPVMP
GQSLQTEMWK EGNRIHIQCK VKETDAVVLS GAYVDLQGAS EASPENLTQG GGLQSELVFA
EIGRRIKDVG SELVKKVNAV FGWEITKDGQ NVAQWTIDLK NGCGALHKGP YSGKADVTFT
VSDDDFMEVV QGKLNPQKAF FSGKLKIRGN IMLSQKLEVI LKDYAKL
//
