ID A0A673AI54_9TELE Unreviewed; 357 AA.
AC A0A673AI54;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Erlin-1 {ECO:0000256|ARBA:ARBA00040567};
DE AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1 {ECO:0000256|ARBA:ARBA00041391};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005028343.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005028343.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family.
CC {ECO:0000256|ARBA:ARBA00008164}.
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DR AlphaFoldDB; A0A673AI54; -.
DR Ensembl; ENSSORT00005029152.1; ENSSORP00005028343.1; ENSSORG00005013420.1.
DR InParanoid; A0A673AI54; -.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR CDD; cd03406; SPFH_like_u3; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR033294; Erlin1/2.
DR PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR PANTHER; PTHR15351:SF2; ERLIN-1; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 42..208
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT REGION 328..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 40186 MW; 11AD550484B43F52 CRC64;
MKKSAMKNSL QRDMKPTNQM TMPHVGAVFA TIAGVMAILL HSSIHKIEEG HLAVYYRGGA
LLTSPNGPGY HIMLPFITTY RSVQTTLQTD EIKNVPCGTS GGVMIYFDRI EVVNMLVPLA
GHKCLKNYTA DYDKTLIFNK IHHELNQFCS VHTLQEVYIE LFDIIDENLK TALQKDLNVM
APGLTIQAVR VTKPKIPEAI RRNFELMEAE KTRLLITAQT QKVVEKEAET ERKKAIIEAQ
KVAQVAEIQF QQKVMEKETE KKISEIEDAA FLAREKAKAD AEYYTAAKFA EANTLKLTPE
YLELMKYQAI AANSKIYFGQ DIPNMFVEGN NSPPKSARPP NLPNIEPDLL KAKLEGQ
//
