ID   A0A673ANZ0_9TELE        Unreviewed;      1109 AA.
AC   A0A673ANZ0;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Sortilin related VPS10 domain containing receptor 3b {ECO:0000313|Ensembl:ENSSORP00005030132.1};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005030132.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005030132.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A673ANZ0; -.
DR   Ensembl; ENSSORT00005030976.1; ENSSORP00005030132.1; ENSSORG00005014390.1.
DR   Proteomes; UP000472271; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF45; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3 ISOFORM X1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00089; PKD; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1030..1048
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          760..814
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1109 AA;  125207 MW;  CA361550C5110249 CRC64;
     MRSASPTARK NYKNTDLRPT DIILEDADPQ QKPRKSRSVA SAHTDNLERS TTGEAQSRDR
     FVEAVQGGSS SRAEHRRTGE DARGSNPRQS EPHLDTSTFA LSGDSAHNQA MVHWSGHNSS
     VILILTKLYD FNLGAVTESS LWRSTDYGST YTKLNDKVGS RTVLSYLYVC PTNKQKIMML
     SDPEVESAVL ISSDEGASFE KYPINFNILS LLFHPAQENW ILAYSHDSKL YSSMDFGKRW
     QLVHENVMPG RFYWAVMGLD RESDVVHIET RIAKSAQYVK CRAQRCSEVN RQYLFNGHVD
     TNSLVVQDEY VFTQVTKSGR ASYFVSYMRE SFKRMKLPKY CLPKDMHIIS TDEKQVFAAV
     QEWNQNNTYS LYISDSPGVY FTLSLENLRT SRGPAGNLLV DFYKVEGING MYLANKLVDN
     QVKTFLTYNK GQTWALLPAP ATDVAGNNLH CILPFCSLHL HLEMSENPYT SGPITSKKSV
     PGIIVATGNI GTELSSTNLG MFITSDAGNS WRQIFDEEHN IWFLDNGGAL LAVLHAAQPI
     RHLWISVDEG KKWDRHSFSL APLYVDGVLM EPESENHIIT FFGHFSYRSE WQLIKIDYKG
     IFSRRCMDGD YQTWHLHNKG EMCVMGEKQV YMKRRPGNRC MLAQDYSRIY SSEPCVCTAY
     DFECDYGWER QTDGKCSPAF WFNPNGAAKS CSNSQSFLNS TGYRKVLSNN CKEGGRNVYS
     PRRQACRPRP PRGLRLSTSQ GELSAAVGSN VTFMVYLEDG DSLRTSIQLD FGDGIRITYS
     NLSRTNDGIK HIYRTTGIYR VTAYAENSQG SDSSTLFLHI TSPVERIYLS APIVTTKGKE
     ANLTVVVWPS HTRTLTFFWW FDNSSEPIIT LEGSISYTFQ KEGKNKVTVQ VASGNTVMQD
     SKVITVKEFF RSLLLSFSPA LDEHNPDIPE WREDIGRVVS GVPGDQLLVS LYPGLPTTAE
     LFILPDEHIP AEHKRRNDEA LETISHIFVT ALNQGLIQFE LKADIRIIVY ITQQTLAPLV
     DSNSIHSGSA MLMLLSVVIV GLAAFFIYKF KRKIPWIHVQ TEDSHEKEPE VISTVSPNDN
     IVLTILVRVE SFQFELCITL TLSSIMEIS
//