ID   A0A673BA91_9TELE        Unreviewed;       961 AA.
AC   A0A673BA91;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE   AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN   Name=pitrm1 {ECO:0000313|Ensembl:ENSSORP00005039291.1};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005039291.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005039291.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC       of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC       {ECO:0000256|ARBA:ARBA00007575}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A673BA91; -.
DR   Ensembl; ENSSORT00005040299.1; ENSSORP00005039291.1; ENSSORG00005016743.1.
DR   Proteomes; UP000472271; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271}.
FT   DOMAIN          443..690
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
FT   REGION          311..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   961 AA;  109170 MW;  B2B10468463AF6F3 CRC64;
     MIRSINTLAI HLFHCYIQNK WPQSCNNFPV KCFGFPSSFR GQTYTWRLKS TSATERALHY
     QPGQKIHGFT VQEVVAVPDL FLTAVKLSHD KTGAQYLHAA REDSNNLFSV QFRTTPMDST
     GVPHILEHTV LCGSEKYPCR DPFFKMLNRS LSTFMNAFTA SDYTMYPFST QNTKDFQNLL
     SVYLDAVFFP CLREQDFWQE GWRLENENPT DPSSRLVFKG VVFNEMKGAF SDNERLYAQH
     LQNKLYPDHT YSVVSGGEPL DIPDLTWDQL KNFHATHYHP SNARFFTYGD LPLEEHLRQI
     EEEALSRFDR INPNTEVPPQ PQWSSPREDH VTCSPDALAP DQSKQNTLCM SYLLGENGFE
     EERIEAILHK IEIQMKHQST NFGLSLASYI ASPWNHDGDP VELLQISDCV SKFRKALREN
     PHFLQDKVQN YFKENTHRLT LSMSPDETYL DKQAKAEEEK LQKKIQALTD SDRKDIYEKG
     LELLSAQSKP QDASCLPALK VSDIEPTIAI TPVHLSSAGG VPVQYCEQPT NGLVYFRAMC
     SLNTLPEELK PYVPLFCSVI TKMGAGSLDY RQQAQQMELR TGGVSVSTQV IPDSTHMDMY
     EQGILLSSSC LDRNLPHMFE LWTDIFSSPH FDDEERLRVL VMMSAQELAN GISYSGHMYA
     MTRTGRHLTP AGDLQETFTG MDQVKFMKRI AEMTDLIHVI RILPRIKKHL LNPDNMRCAI
     NTTPQKMCDA EGQLESFIKD VCGNRKERKP VRPNIIKVSF NVQLWLYSNS NFLPCQMKTF
     FPMPFPVNFI SESIRTVPFS HEDFASLSIL ARMMTAKFLH GEIREKGGAY GGGARMGGGG
     LFSFYSYRDP NLVQTLSAFR GGVDWAKLGQ FTQQDIDEAK LSVFSAVDSP IAPSDKGLGQ
     FLSGITDEMK QGHRQRLFSV THRNLVDVAE RYLSVGQSTR GVAVLGPETD TIKKDPSWIV
     K
//