ID A0A673BRP1_9TELE Unreviewed; 1012 AA.
AC A0A673BRP1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|Ensembl:ENSSORP00005043859.1};
GN Name=slc12a4 {ECO:0000313|Ensembl:ENSSORP00005043859.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005043859.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005043859.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A673BRP1; -.
DR Ensembl; ENSSORT00005044974.1; ENSSORP00005043859.1; ENSSORG00005017143.1.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..221
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 321..621
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 635..753
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 767..845
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 900..1012
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1012 AA; 112912 MW; 732FDDDD88B3B4CA CRC64;
MMPKVSSLLS RLVNYTNITQ GAKEHEEEES AEASRRKTPK SPNMGTLMGV YLPCLQNIFG
VILFLRLTWI VGMAGIIQSL LIVLMCCSCT MLTAISMSAI ATNGVVPAGG AYFMISRSLG
PEFGGAVGLC FYLGTTFASA MYILGAIEIF LKYLVPQAAI FHASDHHGTD SAMLNNMRVY
GSICLSLMAV VVFVGVKYVN KLASLFLACV IISIVSIYAG AIKSMTHPPE FPICMLGNRT
LVRDRFDVCA KTVIKGNITV PSELWESFCS PGNMSSAQCD EYFIQNNVTE IQGIPGLSSG
IIRENMWSDY MPKGEILEKA GLQSVDSHWS METFSMYVSA DIATSFTLLV GIFFPSATGI
MAGSNRSGDL RDAQKSIPVG TILAITTTSL VYLTSVVLFG ACIEGVVLRD KFGDAVNKNL
VVGTLSWPSP WVIVIGSFFS TVGAGLQSLT GAPRLLQAIA KDNIIPFLRV FGHGKPNGEP
TWALLLTGLI AELGILIASL DMVAPILSMF FLMCYLFVNL ACAVQTLLRT PNWRPRFKYY
HWALSFLGMS MCLALMFISS WYYAIVAMGI AGMIYKYIEY QGAEKEWGDG IRGLSLSAAR
YALLRLEVGP PHTKNWRPQL LVLLKLDEDL HVKYPRLLTF ASQLKAGKGL TIVGSVIQGN
FLDSYGEMQA AEQAIKNMME IERVKGFCQV VVASKVREGI VHLIQSCGLG GMKHNTVVMG
WPYGWRQSED PRAWKTFINT VRCTTAAHLA LMVPKNVSFY PSNHERFTDG NIDVWWIVHD
GGMLMLLPFL LKQHKVWRKC RMRIFTVAQM DDNSIQMKKD LATFLYQLRI EAEVEVVEMH
DSDISAYTYE RTLMMEQRSQ MLRQMRLSSA ERQREAQLVK DRHSLVRMGS LYSDEEEEVI
ETPPEKVQMT WTREKVEAER RNKNNAPENF RELISLKPDQ SNVRRMHTAV KLNEVIVNRS
HDARLVLLNM PGPPRNTDGD ENYMEFLEVL TEGLERVLLV RGGGREVITI YS
//
