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Database: UniProt
Entry: A0A673BU84_9TELE
LinkDB: A0A673BU84_9TELE
Original site: A0A673BU84_9TELE 
ID   A0A673BU84_9TELE        Unreviewed;       289 AA.
AC   A0A673BU84;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 11 {ECO:0000256|ARBA:ARBA00039723};
DE   AltName: Full=26S proteasome regulatory subunit RPN6 {ECO:0000256|ARBA:ARBA00041252};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005044152.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005044152.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. In the complex, PSMD11 is required for proteasome assembly.
CC       Plays a key role in increased proteasome activity in embryonic stem
CC       cells (ESCs): its high expression in ESCs promotes enhanced assembly of
CC       the 26S proteasome, followed by higher proteasome activity.
CC       {ECO:0000256|ARBA:ARBA00037179}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). The regulatory particle is made of a lid
CC       composed of 9 subunits including PSMD11, a base containing 6 ATPases
CC       and few additional components. {ECO:0000256|ARBA:ARBA00038658}.
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DR   AlphaFoldDB; A0A673BU84; -.
DR   Ensembl; ENSSORT00005045272.1; ENSSORP00005044152.1; ENSSORG00005020316.1.
DR   Proteomes; UP000472271; Unplaced.
DR   Gene3D; 1.25.40.570; -; 2.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040780; Rpn6_C_helix.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11; 1.
DR   PANTHER; PTHR10678; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF18503; RPN6_C_helix; 1.
DR   SMART; SM00753; PAM; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271}.
FT   DOMAIN          191..271
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|SMART:SM00088"
SQ   SEQUENCE   289 AA;  31993 MW;  9AD5AFEC6455B29F CRC64;
     LCFGPSELGG LLKYAARLVR SLLDLFLDHG GGHGAGGVSC VWSASSGPRP RKRTFLRQAL
     EVTSFRLGSQ LLQELKKMDD KALLVEVQLL ESKTYHALSN LPKARAALTS ARTTAALDMQ
     SAEEKDWKTI MLMPEDVQAL ISGKLALRYA GRQTDSLKCV ALASQNRSLA DFEQALTEYK
     SELRDDPIIS THLTKLYHNL LEQNLIRVIE PFSRVQVGPS PPPESNVERK LSQMILDKKF
     TVGILDQGAG VLIVFEEPVV DQTYESALET IHNMSKVVDS LYNKAKKLT
//
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