ID A0A673BXY5_9TELE Unreviewed; 2771 AA.
AC A0A673BXY5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Neurofibromin 1b {ECO:0000313|Ensembl:ENSSORP00005046625.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005046625.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005046625.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSSORT00005047787.1; ENSSORP00005046625.1; ENSSORG00005017597.1.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271}.
FT DOMAIN 1193..1386
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1515..1673
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2679..2701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2716..2771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2716..2761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2771 AA; 311846 MW; 4D5C90F8391CD45F CRC64;
MAAHKPVEWV QAVITRFDEQ LPIKVGHQNT HTKISTEHNK ECLINISKYK FSLVISGLTN
ILKNVNNMRI FGEASEKNLY LSQLIILDTL EKCLAGQSKD CLRLDETMLV KQLLPEICHF
IHTYREGHQH ATELRASASA VLFSLSCNNF NAVFSRISTR LQELTVCSED NVDVHDIELM
QYINVDCSKL KRLLQETVLK FRALKKPAQL AVINSLEKAF WNWVENYPDE FTMLYQRPQA
DMAEAAEKLF DLVDSFAESA KRKAAVWPLQ IILLILCPEI THTISKDTVE DSKANKKLFV
DNLRKALAGQ GGSKQLMESA AIACVKLCKA STYINWEDHS TIFLLVQSIV MDLKALLFNP
AKPFWRGTGS QNADVELMMD CFVSCFRINP HNNQHFKVCL ASSSPSTFHF VLVNSLHRII
TNSHLDWWPK IDAVYCYSGE LRFMFSDTLN RVIQGIATHA PLRMTPSLTF KGKVTTSLKF
KEKATELDTR SYKCLLLALV KLIHPCFVKQ ASEMQSSTAE LITGLVQLVP LTNTTQLSQE
AMEALLVLHQ PETIELWNPD APIETFWDIS SQVLSLICRK LIGQQMVNGT EVLKWLREIL
ICRNKFLLKN KVTDRRSDST SSLLQTLEVS EPCVTWCVQE SATMGGGIPI CRQAQTKLEV
SLYMFLWSPD TEAVLVAMSC FRHLCEEADI RSAADEVPVQ TILPNYATFS ELASVSNMMG
TGRSTLQKRV MALLRRIEHP TPGNIEAWED TYAKWDQATK QILNFPKNKA DDGLFYVLCV
TNSPGVLLQQ EWINMTGFLC ALGGVCLQQR STPGPATYSP PMGPMAERKH SMISMGPCEA
PNAVSSTPVS RFLDRLLSLL VCGHDRVGLH VRTNVKDLLG LELSPALYPM LFNKLRNSIG
KFFDTQGPVP INDTNTQFVE QTIAIMKNLL DNHTEGSSEH LGQASIETMM LNLVRYVRIL
GNVVHAIQIK TKLCQLVEVM MERRDDLSFC QEMKFRNKMV EYLTDWVMGT SNQAADDDIK
CLTRDLDQAS MEAVVSLLAG LPLQPEEGDG VELMEAKSQL FLKYFTLFMN LLNDCSEVED
EGQAVGGRKR GMSRRLASLR HCTVLAMSNL LNANVDSGLM HSIGLGYHKD LQTRATFMEV
LTKILQQGTE FDTLAETVLA DRFERLVELV TMMGDQGELP IAMALANVVP GSQWDELARV
LVTLFDSRHL LYQLLWNMFS KEVELADSMQ TLFRGNSLAS KIMTFCFKVY GAAYLQKLLE
PLLRGVITTP EHISFEVDPT RLEQGENLEE NQRNLLQITD RFFQAIIGSS SEFPPQLRSV
CHCLYQVVSQ RFPQNSIGAV GSAMFLRFVN PAIVSPYEAG ILDKKPLPRI ERGLKLMSKI
LQSIANHVLF TKEEHMRPFN DFVKSNFDSA RRFFLDIASD SPPSDSVNHS LSFISDGNVL
ALHRLLWNNQ ERIGQYLSSN RDHKAVGRRP FDKMATLLAY LGPPEHKPVA DTHWSSLNLT
SSKFEEFMTR HQVHEKEEFK ALKTLNIFYQ AGTSKTGNPV FYYVARRFKT GQINGDLLIY
HVLLTLKPYY AKPYEIVVDL THVGPSNRFK TDFLSKWFVV FPGFAYENVA AVYVYNCNTW
VREYTKYHER LLTGLKGSKR LQFIDSPAKL AEHIEPEQQK LPAATLTLEE DLKVFHNALK
LAHKDTKVSI KVGSTAVQVT SAERTRVLGQ PVFLNDVYYA SEIEEICLVD ESQFTLTMAN
QGTPLTFMHQ ECDAIVQSII HIRTRWELSQ PDSIPQHTKI RPKDVPGTLL NIALLNLGSS
DPSLRSAAYN LLCALTCTFN LKIEGQLLET SGLCIPANNT LFIVSISKTL AANEPHLTLE
FLEECISGFS KSSIELKHLC LEYMTPWLLN LVRFCKHNDD AKRQRVTAIL DKLITMTINE
KQMYPSIQAK IWGSLGQITD LLDVVLDSFI KTSATGGLGS IKAEVMADTA VALASGNVKL
VSSKVIGRMC KIIDKTCLSP TPTLEQHLMW DDIAILARYM LMLSFNNSLD VAAHLPYLFH
VVTLLVATGP LSLRASTHGL VINIIHSLCT CSQLNFSEET KQVLRLSLTE FSLPKFYLLF
GISKVKSAAV IAFRSSYRDR SFSPGSYERE TFALSSLETV TEALLEIMEA CMRDIPSCKW
LDQWTELAQK FAFQYNPSLQ PRALVVFGCI SKRVSHGQIK QIIRILSKGL ESCLKGPDNY
NSQVLIEATV IALTKLQPLL SKESPMHKAL FWVAVAVLQL DEVNLYSAGT ALLEQNLHTL
DTMRVFNDKS PEEVFMEIRR PLEWHCKQMD HFVGLNFSAN FNFALVGHLL KGYRHPSPTT
VARTVRILHT LLALISKNLK CDKFEVNTQS VAYLAALLTV SEEVRSRCSL KHRKSLLISD
LSIDPVPMDT YSSHISDPSC RTLRETQPWT SPQVSDRYLS AHHYPTVGQI SPRTRKSMSL
DMGQPSQANA KKLLGTRKSF DHLISDSKAP KRPEMESGMT TPPKMRRVAE NDYEIETQRI
ANSHLRKVSV SESNVLLDEE VLTDPKIQAL LLTVLATQVK YTTDDFDQRI LYEYLAEASV
VFPKVFPVVH NLLDSKINTV LSMCQDTNLL NPVHGIVQSV VYHEESPPQY QPSYLQSFGF
NGLWRFAGPF SKQTQIPDYA ELIVKFLEAL IDSYLPAADE ERGEEQLRTP TSPYPPTSQS
QLSITANLNL SNSMTSLATS QHSPGVDKEN VQLSPSSALS SGGRTRHGSA SQVQKQRSAG
SFKRPSIKKI V
//
