ID A0A673BY91_9TELE Unreviewed; 1121 AA.
AC A0A673BY91;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 7b {ECO:0000313|Ensembl:ENSSORP00005046009.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005046009.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005046009.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A673BY91; -.
DR Ensembl; ENSSORT00005047164.1; ENSSORP00005046009.1; ENSSORG00005014208.1.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..303
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 414..696
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 710..828
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 832..967
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1010..1121
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..963
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 124059 MW; C621A56708BFE5C9 CRC64;
MPTNFTVVRV KDSAGKATEG NDEDVDENNV LKEEEEDATG DGVPKENSPF INNTDNDKAN
SYDGTNMALF EEEMDSNPMV SSLLNKLANY TNLTQGAQEH EEADDDEGTK KKTVKSPQMG
TFMGVYLPCL QNILGVILFL RLTWIVGTAG ILESLAIVGL CCSCTMLTAI SMSAIATNGV
VPAGGSYYMI SRSLGPEFGG AVGLCFYLGT TFAGSMYILG TIEILLTYIV PKAAIFVAER
KEDEVDALLN NMRVYGTCCL ALMAIVVFVG VKYVNKLALV FLACVILSIL AIYAGVIKTI
FEPPDFPVCM LGNRTLQNHN FDKCLKTEIK DNITVTTQLW NLFCEGPELN ATCNEYFDNN
NVTEVQGIPG LTSGVISENM WPEYGPLGML VENKKLASVP GGDPKQDIYM PYVVNDITTF
FTLLVGIYFP SVTGIMAGSN RSGDLRDAQK SIPIGTILAI ATTSFIYISC VVLFGACIEG
VLLRDKFGDS VKGNLVIGTL SWPSPWVIVI GSFFSCCGAG LQSLTGAPRL LQAIARDGIV
PFLQVFGHGK ANGEPTWALL LTAGICEIGI LIASLDAVAP ILSMFFLMCY LFVNLACAVQ
TLLRTPNWRP RFKYYHWALS FLGMSLCLAL MFISSWYYAI VAMAIAGCIY KYIEYRGAEK
EWGDGIRGLS LNAARYALIR LEDAPPHTKN WRPQLLVLLN LDSDQGVKHP RLLSFTTQLK
AGKGLTIVGN VLEGTYLTKD TESKKAEQNI KACMSAERTK GFCHVVVSSN LRDGVSHLIQ
SAGLGGMKHN TVLMAWPGTW KQSNDPQSWK SFIETVRETT SAHQALLVAK NVDSFPTNQD
RLGEGTIDVW WVVHDGGMLM LLPFLLRQHK VWRKCKMRIF TVAQMDDNSI QMKKDLQMFL
YHLRLDAEVE VVEMHDNDIS AFTYEKTLVM EQRSQMLKQM QLSRTERERE IQSITDESRS
SIRRKNQGAA PGTSLSRQSS TAEDTQEDEA QLIHDRNTAS HTTINDKADA GPERVHMTWT
KDKLFTERRN RECNANVAVR DLFNMKPNQS NVRRMHTAVK LNEVVVNKSQ GAHLVLLNMP
GPPKNRGGDE NYMEFLEVLL EGLNRVLLVR GGGREVITIY S
//
