ID A0A673BZB6_9TELE Unreviewed; 1030 AA.
AC A0A673BZB6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 7b {ECO:0000313|Ensembl:ENSSORP00005046027.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005046027.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005046027.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A673BZB6; -.
DR Ensembl; ENSSORT00005047182.1; ENSSORP00005046027.1; ENSSORG00005014208.1.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..303
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 414..696
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 710..828
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 830..1030
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 113843 MW; 298640C66C6AFC86 CRC64;
MPTNFTVVRV KDSAGKATEG NDEDVDENNV LKEEEEDATG DGVPKENSPF INNTDNDKAN
SYDGTNMALF EEEMDSNPMV SSLLNKLANY TNLTQGAQEH EEADDDEGTK KKTVKSPQMG
TFMGVYLPCL QNILGVILFL RLTWIVGTAG ILESLAIVGL CCSCTMLTAI SMSAIATNGV
VPAGGSYYMI SRSLGPEFGG AVGLCFYLGT TFAGSMYILG TIEILLTYIV PKAAIFVAER
KEDEVDALLN NMRVYGTCCL ALMAIVVFVG VKYVNKLALV FLACVILSIL AIYAGVIKTI
FEPPDFPVCM LGNRTLQNHN FDKCLKTEIK DNITVTTQLW NLFCEGPELN ATCNEYFDNN
NVTEVQGIPG LTSGVISENM WPEYGPLGML VENKKLASVP GGDPKQDIYM PYVVNDITTF
FTLLVGIYFP SVTGIMAGSN RSGDLRDAQK SIPIGTILAI ATTSFIYISC VVLFGACIEG
VLLRDKFGDS VKGNLVIGTL SWPSPWVIVI GSFFSCCGAG LQSLTGAPRL LQAIARDGIV
PFLQVFGHGK ANGEPTWALL LTAGICEIGI LIASLDAVAP ILSMFFLMCY LFVNLACAVQ
TLLRTPNWRP RFKYYHWALS FLGMSLCLAL MFISSWYYAI VAMAIAGCIY KYIEYRGAEK
EWGDGIRGLS LNAARYALIR LEDAPPHTKN WRPQLLVLLN LDSDQGVKHP RLLSFTTQLK
AGKGLTIVGN VLEGTYLTKD TESKKAEQNI KACMSAERTK GFCHVVVSSN LRDGVSHLIQ
SAGLGGMKHN TVLMAWPGTW KQSNDPQSWK SFIETVRETT SAHQALLVAK NVDSFPTNQD
RLGEGTIDVW WVVHDGGMLM LLPFLLRQHK VWRKCKMRIF TVAQMDDNSI QMKKDLQMFL
YHLRLDAEVE VVEMHDNDIS AFTYEKTLVM EQRSQMLKQM QLSRTERERE VIYKSFPKSN
VRRMHTAVKL NEVVVNKSQG AHLVLLNMPG PPKNRGGDEN YMEFLEVLLE GLNRVLLVRG
GGREVITIYS
//