ID A0A673C1Y6_9TELE Unreviewed; 1023 AA.
AC A0A673C1Y6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005047274.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005047274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR AlphaFoldDB; A0A673C1Y6; -.
DR Ensembl; ENSSORT00005048448.1; ENSSORP00005047274.1; ENSSORG00005019448.1.
DR InParanoid; A0A673C1Y6; -.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Synapse {ECO:0000256|ARBA:ARBA00022599};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 39..317
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 518..708
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 737..834
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 910..1007
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 116858 MW; 7D60DC167B588497 CRC64;
MFLAQSSGAG QRLGAPETLG ISTLDPGHRP PAMPPGRQVT IRVRMLDDTE ELFDISMGIL
ILETVLYSSL KQWSGNRLAW QLLDVKLLNV WLDHIKPIIK QLRRPKHTIL RFSVKFFPPD
HAQLLEELTR YLFALQIKQD LSGGRLTCND SSAALMVSHI IQSEIGDFEE SQCRSHLLNN
NYIPDQMPLI DKIMEFHSKN IGHTPAESDY QLLEVARRLE MYGIRLHPAK DREGTRLSLA
VAHTGVLVFQ GHTKINAFNW AKVRKLSFKR KRFLIKLRPD LNSSYQDTLE FLMASRDCCK
VFWKICVEYH AFFRLFEEPK PKPKPVLFSR GSSFRFSGRT QKQVIDYVRE SEFKKIPFER
DSSPRCHWKE SVLVSAEDPS ASRTTRASPY HQRNGHEDRP GPGSRIEETR CSPRQTHPEP
PSTGPASRAA KGSSSSISYN DCANVESEYN MGRDLAISPH LSGLSHGMVN GQKSLELCSH
SPDGRQPSPL TSPLLNDACS IRTDDEDDVR RKRFPTDRAY FIAKELLTTE RTYVKDLEVI
TSFQSAVGQD EATPDSLKTT IFSTFEPLHK FHTGFLREVE QRLALWEGRS NAHIKGDYQR
IGDVMLKNLQ DLKPLTTNLH KQSEVLVELE KACRLSRRLE GLCRDFELQK VCYIPFNVFI
LRPLHRLIHY KQILERLCKH YPATHVDFRD SRAALADVSE VVDQLQGSII KMENFQKLLE
LKKDLIGVDN LVVPGREFIR LGCLSKLSGK GLQQRMFFLF NDVILYTSRG MTATNQFKVH
GQLPLQGMTI RESEDEWGVP HAFTLVGQQQ SVVVAASSLT EMEKWMEDIK VAIEMAKTSN
GPSSDLLTSN MTDNSKSQHD SSVEAESEDD TTASHASTER PAPHRGNTMV HVCWHRNTSV
SMVDFSIAVE NQLSGNLLRK FKNSNGWQKL WVVFTNFSLF FYKSHQDDYP LASLPLLGYS
VTIPSESENI HKDYVFKLHF KSHVYYFRSE SEYTFERWME VIRSATVPSS RSRVLNSKES
HPH
//
