ID   A0A673C803_9TELE        Unreviewed;      1409 AA.
AC   A0A673C803;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE            EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005051696.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005051696.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC   -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC       {ECO:0000256|PIRNR:PIRNR006743}.
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DR   Ensembl; ENSSORT00005052929.1; ENSSORP00005051696.1; ENSSORG00005023335.1.
DR   Proteomes; UP000472271; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 2.170.260.40; -; 1.
DR   Gene3D; 2.30.30.750; -; 1.
DR   Gene3D; 3.40.50.12390; -; 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016494; 5_3_exoribonuclease_1.
DR   InterPro; IPR041385; SH3_12.
DR   InterPro; IPR040992; XRN1_D1.
DR   InterPro; IPR047007; XRN1_D1_sf.
DR   InterPro; IPR041106; XRN1_D2_D3.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR047008; XRN1_SH3_sf.
DR   PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF18129; SH3_12; 1.
DR   Pfam; PF18332; XRN1_D1; 1.
DR   Pfam; PF18334; XRN1_D2_D3; 1.
DR   Pfam; PF17846; XRN_M; 2.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW   RNA-binding {ECO:0000256|PIRNR:PIRNR006743};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1255..1274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1281..1302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..227
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          274..328
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          361..595
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          640..820
FT                   /note="5'-3' exoribonuclease 1 D1"
FT                   /evidence="ECO:0000259|Pfam:PF18332"
FT   DOMAIN          832..1057
FT                   /note="Exoribonuclease Xrn1 D2/D3"
FT                   /evidence="ECO:0000259|Pfam:PF18334"
FT   DOMAIN          1085..1154
FT                   /note="5'-3' exoribonuclease 1 SH3-like"
FT                   /evidence="ECO:0000259|Pfam:PF18129"
FT   REGION          1228..1249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1409 AA;  160704 MW;  BCF23D86F5CAF7B9 CRC64;
     MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDED VHFRISEEKI
     FADIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAEE KIKKALDKGE
     VLPTEARFDS NCITPGTDFM ARLQEQLKYF VYNKLSTDKM WQKVKVYLSG HETPGEGEHK
     IMEFIRAEKA KPGHNPNTRH CLYGLDADLI MLGLTSHEPN FSLLREEVRF GGKKSQKRIT
     APEETTFHLL HLSLMREYID YEFSELRNHI GADYDLERII DDWILMGFLV GNDFIPHLPN
     LHINHDALPL LYKTYISVLP EWNGHLNLRN FEKYLEKLSE FDREHFSEVF VDLKWFESKV
     GNKYLNEAAG LAAEKEADSA LCLAALSSSE RMTGEGKGTV ADEEEEEDDI FETEFRQYKR
     TYYMTKMGVD VVSDEFLATQ ARCYVEGIQW ILHYYYHGVQ SWSWYYPYHY APFLSDIKNL
     SELKLTFDLG TPFMPFQQLL AVLPAASMEL LPECYRHLMT SERSPIIEYY PLDFKTDLNG
     KQQEWEAVVL IPFIDERCLL AAMEPYNSKL TQGEKARNRH TECAIYTYDK ESEFTYSSPL
     PQMFPDIIHC RVRKTDIPMD AWHVPPDHVS GRIDRSALYF CGFPTLQHIK HKFYKKKSGV
     VVFQQSSRGE NMMLEITGSD AETTCDEVAA QTVGKSIFVN WPHLEEARIV AVSDGETKFS
     LEEPPGVQRV YDRPSTPPPT KVTCLSDKEQ KDWLKDVQGI TEHYLKRKGI FVNECEVLLY
     GQLLTGRKYV PKANGVVELE KQWAKQVLPF AHQTVVKDIK AFYSSLTCFT SLDELFPQTT
     TVFMVGNPYY GAMGEVQDSS DVIKEGRVRV VFNVPHEPQL EPLIQNQHKY CVKYSPGYVL
     ASRLGITSYL VSRFSGSIFI GRGSKKNPCG EQRANVGLNL KFNKKNEEVP GYTKRTEKEW
     LYSAAVEELL AEYLDRFSEV FNTVSRNSHD DVFYEDDIWP GEDQNGAEKV AEITSWLKGH
     PVSSISRASC DLQVLDSAIV ERIEEAVEKT KVKKSTRKVR VTVKPHLLFR PLEQQQGVVP
     DPDAEYRLFD RVVNIRESFT VPLGLRGTVI GIKGAEREAE VLYEVLFDEE FAGGLTIRCT
     APRGYRLPPC ALINLSHGAR VDHTSHKLTA IVKPQPAAAA NFNSNRQLGG LNHSPRSPFI
     PTQVRPIQTL THEERLYQYF ITNLKISKGS QQTPPPPALP QASTSQSDGP LSPQSFAMVS
     VGVKSFVFIA SILISFFHDY VLCYAMLCYV LFCSVVSVIL AAKINVPHGE SASPIAPPSA
     NFSNAMMGSK VSELACVCVG LGMTPPDFSF IRSRQGLVVC QVKLSNGLMV HGPQCQSEND
     AKEKAAFFAL QRLQSMFTFV RNKKIFECK
//