ID   A0A673C935_9TELE        Unreviewed;      1012 AA.
AC   A0A673C935;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Nardilysin-like {ECO:0000313|Ensembl:ENSSORP00005050515.1};
GN   Name=LOC115418199 {ECO:0000313|Ensembl:ENSSORP00005050515.1};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005050515.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005050515.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   AlphaFoldDB; A0A673C935; -.
DR   Ensembl; ENSSORT00005051727.1; ENSSORP00005050515.1; ENSSORG00005021486.1.
DR   Proteomes; UP000472271; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          95..224
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          250..422
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          428..709
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          714..876
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          30..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..82
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1012 AA;  115494 MW;  60573732119D2150 CRC64;
     MYLLSLSCLF RYIELSNGLR VLLISDFSGS NAKGGGDDQQ DQAGAQGRDE VEEEEEGDSG
     EGSEEDEEEN EEEEQDSDFD ELDEENAGKK KKGSSEKQAA AALCISVGSF SDPDDLPGLA
     HFLEHMVFMG SEKYPAENGF DAFLKKHGGS DNASTDCERT IFQFDVQRKY FREALDRWAQ
     FFICPLMIED AIDREVEAVD SEYQLARPSD SHRKEMLFGS LAKPGHPMSK FCWGNAQTLK
     HEPRDKQINT YQRLRDFWKR YYSAHYMTLA VQSKGTCDSK TGEPRPDFSH LQQPFDTPAF
     NKLYRVVPVR KVHALTISWA VPPQGKHYRV KPLHYISWLI GHEGTGSILS LLRKKCWALA
     LFGGNSETGF DQNTTYSIFS ISITLTDQGY QNFYQVVHLV FQYLKMLQNL GPQQRIYEEI
     QKIEANEFHY QEQTDPIEFA ENICENMQLF PKEDFLTGDQ LMFEYDPQVI SAALSLLTPD
     KANLLLLSPE NEGHCPLREK WFGTCYNMED VPDEWVQRWA GDFQLNPDLH LPAHNQFIAT
     DFTLKTSDCP DTEFPVRIIT SDRGALWYKK DNKFKIPKAY IRFNLISPMI QKSPENLVLF
     DLFVNILAHN LAEPAYEADV AQLEYKLVAG EHGLVIRLKG FNHKLPLLLK LIVDHLAEFS
     AEPAVFAMFS EQLKKTYFNI LIKPERLGKD VRLLILEHCR WSVIQKYQAL MKGLTVDDLM
     TFATQLKAEL YVEGLVQGNF TSTESKEFLQ DFTQKLQFQP LTAEVPVLFR VVELPQKPHL
     CKVKSLNKGD ANSEVTVYYQ MHMEEPCFDF LRTKETLGYQ VYPTCRNTSG VLGFSVTVET
     QATKFSSEFV EAKIEEFLVS FGERLSGLSE DAFKTQVTAL IKLKECEDAH LGEEVDRNWF
     EVVTQQYVFD RLNKEVRNQF NVSLCFTHVS TRCFSGPRQV VGFGVEENDP SDQSVLCPSD
     GADNPPSSAY GEVSELSFLP AWTPQLQDAA LITDIRAFTA SLPLHPYHKI LH
//