ID A0A673CQF2_9TELE Unreviewed; 917 AA.
AC A0A673CQF2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 2 {ECO:0000313|Ensembl:ENSSORP00005057861.1};
GN Name=scube2 {ECO:0000313|Ensembl:ENSSORP00005057861.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005057861.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005057861.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A673CQF2; -.
DR Ensembl; ENSSORT00005059182.1; ENSSORP00005057861.1; ENSSORG00005025587.1.
DR Proteomes; UP000472271; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 5.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..917
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025329406"
FT DOMAIN 28..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 302..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 343..381
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 729..841
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 347..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 917 AA; 102121 MW; 3D287B2AE1E1919D CRC64;
MGAIWAARDF CLFLLLLNSR QSAALPEIRD PCAEGSDGCH IDAICQTTQG SYKCTCKAGF
KGDGKHCEDT DECDFEYNGG CVHECNNIPG NYRCTCYDGF NLAHDGHNCL DVDECKFNNG
GCQHTCVNTM GSYECRCKEG FFLSDNQHTC IHRSVEGLNC MNKEHGCAHI CKETPKGGVA
CECRPGFELA RNQRGCILTC NHGNGGCQHT CEDTENGPIC KCHPRYSLQP DRRSCVATTE
SSDHNTTSFT EVDKRVKRRL LMETCAVNNG GCDCTCKDTS TGVRCSCPVG FTLQPDGKTC
KDIDECELHN GGCDHFCRNT IGSFECNCRK GFKLLTDERS CQDIDECFFE RTCDHTCVNS
PGGFQCLCNK GYTMYGLAHC GDINECSVNN GGCEQGCENT MGGFECFCHP GYKLHWNKKD
CIEAEGLPPA NPPFKPTLNC SKQEGGDRCF LTCQSQVHIS SASVYVQSAS AVLDDTLLWR
QLWYGVLFSA ESCDLNCVRR RSEKRLRKTI RTLRKSINRE QFHLHFAGSD YELAKSLVQP
AELPGHCVAG QVLVNRKCVS CSAGTYYDGD QGRCVLCPAG TYQDEEGQMS CEVCPGPEGR
EISKVVGARN LSECGGQCPP GQYSHDGFIP CLPCPLGTYQ PEVGRTSCFP CGGSLVTKRP
GAVTFQECET KVQCSPGHYY NTSTHRCIRC PTGTYQGEFG QNYCIACPGN TTTDFDGSTN
IMQCKNRQCG GELGDFTGYI ESPNYPGNYP ANIECTWTIN PPPKRRILIV VPEIYLPIED
ECGDYLVMRK SSLSNSVTTY ETCQTYERPI AFTSRSKRLW IQFRSNEGNS GKGFQVPYVT
YDEDYQELIE DIVRDGRLYA SENHQEILKD KKLMKALFDV LAHPQNFFNY TAQESREMFP
KSFIRFLRSK VLRFLRP
//
