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Database: UniProt
Entry: A0A673TU66_SURSU
LinkDB: A0A673TU66_SURSU
Original site: A0A673TU66_SURSU 
ID   A0A673TU66_SURSU        Unreviewed;       362 AA.
AC   A0A673TU66;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Tyrosyl-DNA phosphodiesterase 2 {ECO:0000256|ARBA:ARBA00017870};
DE   AltName: Full=5'-tyrosyl-DNA phosphodiesterase {ECO:0000256|ARBA:ARBA00031304};
OS   Suricata suricatta (Meerkat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX   NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005015418.1, ECO:0000313|Proteomes:UP000472268};
RN   [1] {ECO:0000313|Ensembl:ENSSSUP00005015418.1, ECO:0000313|Proteomes:UP000472268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA   Clutton-Brock T.H.;
RT   "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSUP00005015418.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC       {ECO:0000256|ARBA:ARBA00004322}.
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DR   AlphaFoldDB; A0A673TU66; -.
DR   Ensembl; ENSSSUT00005017594.1; ENSSSUP00005015418.1; ENSSSUG00005009936.1.
DR   OMA; AENDWDM; -.
DR   OrthoDB; 276861at2759; -.
DR   Proteomes; UP000472268; Chromosome 7.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09080; TDP2; 1.
DR   CDD; cd14344; UBA_TYDP2; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF14555; UBA_4; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472268}.
FT   DOMAIN          117..351
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
FT   REGION          65..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   362 AA;  40627 MW;  2B4F6F8F89B5947C CRC64;
     MEGPSGSLVT LEADRAEGEP EAKKRRLLCV EFASVANCDS AVAQCYLAEN DWEMERALNS
     YFEPPVEDGA LEDRPETPEA HESCVDLTNE ETTDSISCKT STSEGAQQED GSSFSFITWN
     IDGLDLNNLP ERARGVCSYL TLYSPDVIFL QEVIPPYCSY LKKRANSYEI ITGHEEGYFT
     AIMLKKSRVK FKSQEIIPFP NTKMMRNLLC VYASASGNEL CLMTSHLEST RGHAKERMDQ
     LKMVLKKMQE VPESATVIFA GDTNLRDHEV TKCGGLPSNI LDVWEFLGKP KHCQYTWDTQ
     MNSNLGISAT CKLRFDRIFF RTAAESGHIV PQSLDLLGLE KLDCGRFPSD HWGLLCNLEV
     IL
//
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