ID A0A673TYF0_SURSU Unreviewed; 943 AA.
AC A0A673TYF0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=XPC complex subunit, DNA damage recognition and repair factor {ECO:0000313|Ensembl:ENSSSUP00005014066.1};
OS Suricata suricatta (Meerkat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005014066.1, ECO:0000313|Proteomes:UP000472268};
RN [1] {ECO:0000313|Ensembl:ENSSSUP00005014066.1, ECO:0000313|Proteomes:UP000472268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA Clutton-Brock T.H.;
RT "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSUP00005014066.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR AlphaFoldDB; A0A673TYF0; -.
DR Ensembl; ENSSSUT00005016060.1; ENSSSUP00005014066.1; ENSSSUG00005008993.1.
DR OMA; FQAKHLG; -.
DR Proteomes; UP000472268; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd21393; sm_acid_XPC-like; 1.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 2.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR NCBIfam; TIGR00605; rad4; 1.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000472268}.
FT DOMAIN 634..686
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 688..748
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 755..829
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..143
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 105273 MW; 1BC9C7325C641E18 CRC64;
MARKRAAGRE PQGREPCGRK AKGKSTARRE EKEADVLEDE KPLKRSLLSK VSRETRKRGC
GDPGGPANSP ARKKAAKVTV KSENAEVKDE ALSDGEDLRD FASTPKKAPH PRKEAAVDKG
GCEGDDEEES EDDWEEVEEL SEPVPGDVGE NAVFSKSVLP MKPVEIEIET PQQAKARERS
ERIKMEFETY LRRMMNRFSK EVHEDTHKVH LLCLLANGFY RSSICSQPDL LAVGLSIVPA
RFTKVPPQDV DICFLSNLVK WFIGTFTVNA DLSTNEQDGL QTTLERRFAI YSARDDEELV
HIFLLILRAL QLSTRLVLSL QPIPLKLPTA KGKKASKEKS TEGPGGSLEP SSPDPENQAR
PKSSKGTRRE STPSAGSGSP SALGRRRKAA AVGKKRSVPS SSEEEEWKAG GQEEGPRGRR
QAPERQAASR VSYKESGSEK GSSGSDFELS GGEVHHSSDE DSEPGRPRHR RARVPQRKTS
GSKSDSRPQH GRHPKRSGLP AASTSSSSSK SKRGKELPSD GEGAQRGKTA GIDQWLEVFC
EQEEKWVCVD CVHGVVGQAV ACYKYASKPM TYVVGIDSDG WVRDVTQRYD PAWMTTTRKF
RVDAKWWAET LRPYQSPLVE REKKEDSEFQ AKHLGQPLPT VIGTYKNHPL YALKRHLLKY
EAIYPETAAI LGYCRGEAVY SRDCVHTLHS RDTWLKQARV VRLGEVPYKM VKGYSNRARK
ARLAEPQLQD QNDLGLFGRW QTEEYQPPVA VDGKVPRNEF GNVYLFLPSM MPVGCVQLNL
PNLHRIARKL GIDCVQAVTG FDFHKGYSHP ITDGYIVCEE YKDVLLAAWE NEQALIEKKE
KEKREKRALG SWKLLVRGLL IRERLKLRYG DKSEAAAAQA HVGGGLSSDE EEGTSSQAQA
SRILAASWPQ NREAEAEQKP QSPKKTKRER RAAASHLFPF ERL
//
