ID A0A673UW43_SURSU Unreviewed; 708 AA.
AC A0A673UW43;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=MCF.2 cell line derived transforming sequence-like 2 {ECO:0000313|Ensembl:ENSSSUP00005025415.1};
OS Suricata suricatta (Meerkat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005025415.1, ECO:0000313|Proteomes:UP000472268};
RN [1] {ECO:0000313|Ensembl:ENSSSUP00005025415.1, ECO:0000313|Proteomes:UP000472268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA Clutton-Brock T.H.;
RT "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSUP00005025415.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A673UW43; -.
DR Ensembl; ENSSSUT00005029069.1; ENSSSUP00005025415.1; ENSSSUG00005015645.1.
DR Proteomes; UP000472268; Chromosome 5.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF211; GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472268}.
FT DOMAIN 11..193
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 614..708
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 530..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 322..369
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 546..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 81182 MW; 144EEC5FA8B64321 CRC64;
MLFWLKEEMA PQELSRRLAT VITHVDEIMQ QEIRPLVAVD IIEQLHRQFA ILSGGRGKDG
APIITFPEFV GFKHIPEEDF LNVMTYLTSI PSVEAASIGF VVVIDRRRDK WSSIKASLTR
IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI KYYRDEFKMK VPIIMLNSAS DLHGYIDKSQ
LTEDLGGTLE YRHSQWINHR TAIENFAVTL KTTAQMLQMF GACLATTELP RGVLSTEDLL
MSHTGQRDKL RDELKLLGKQ GATLLSCIQE PATKSPTSIL NPNQLENVVT VERLLLQLDE
TEKAFNQFWS EHHLKLNQCL QLQHFEHNFH EVKRALNNLL AEQAEFTDIG DSVIRVEQLL
KEHKKLEEEG QEPLEKAQLL AVIGDQLIQS HHYAADSIRP RCVELRHLCD DFINENKKKH
DILEKSLELH RQLDKVSQWC EAGIYLLASQ AVDKCQSREG VDVALNDIEA FLGTAKEYHL
PSHTEFYSQF ELILTLDVKA KAQEVLQKLG DVQEIFHKRQ MSLMKLAARQ TRPVQPVAPH
PESSPKWVSP KTSQPSTLAS LAPLQRTSEE PYTGTVEKDD ETKFEVKNEE ILESSHDGEN
PEPEQLDSPA TLSPTRCIIR DLLETEEIYI KEIKSIIDGY ITPMDFIWLK HLIPDVLQNN
KELLFGNITE LYEFHNRTFL KELEKCTENP ELLARCFLKR VSLGYQVK
//
