ID   A0A673UZU5_SURSU        Unreviewed;       209 AA.
AC   A0A673UZU5;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=COP9 signalosome subunit 7B {ECO:0000313|Ensembl:ENSSSUP00005026841.1};
OS   Suricata suricatta (Meerkat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX   NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005026841.1, ECO:0000313|Proteomes:UP000472268};
RN   [1] {ECO:0000313|Ensembl:ENSSSUP00005026841.1, ECO:0000313|Proteomes:UP000472268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA   Clutton-Brock T.H.;
RT   "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSUP00005026841.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of SCF-
CC       type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC       of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC       involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA,
CC       ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
CC       kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and
CC       protects degradation by the Ubl system, respectively.
CC       {ECO:0000256|ARBA:ARBA00025037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008482}.
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DR   AlphaFoldDB; A0A673UZU5; -.
DR   Ensembl; ENSSSUT00005030687.1; ENSSSUP00005026841.1; ENSSSUG00005017333.1.
DR   Proteomes; UP000472268; Chromosome 3.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR041481; CSN7_helixI.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR   PANTHER; PTHR15350:SF8; COP9 SIGNALOSOME COMPLEX SUBUNIT 7B; 1.
DR   Pfam; PF18392; CSN7a_helixI; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472268}.
FT   DOMAIN          29..122
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|SMART:SM00088"
FT   REGION          167..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   209 AA;  23516 MW;  99FD367AB716A690 CRC64;
     MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA NVQECIPYSV
     LLKDLEMRNL RELEDLIIEA VYTDIIQGKL DQRNQLLEVD FCIGRDIRKK DINNIVKTLH
     EWCDGCEAVL LGIEQQVLRA NQYKESHSRT QQQIEAEVTN IKKTLKATAS SSAQEMEQQL
     AERECPPHAE QRQPTKKMSK VKGLVSSRH
//