ID A0A673WCR9_SALTR Unreviewed; 1107 AA.
AC A0A673WCR9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSSTUP00000006863.1};
GN Name=LOC115195632 {ECO:0000313|Ensembl:ENSSTUP00000006863.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000006863.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000006863.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A673WCR9; -.
DR Ensembl; ENSSTUT00000007298.1; ENSSTUP00000006863.1; ENSSTUG00000002849.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 97..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..275
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 393..674
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 688..806
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 817..942
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1040..1107
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 12..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 122051 MW; 5C0637041B9C26E6 CRC64;
LNMFVFSKTV SSASTGDGMP KESSPFINNT DNDKGNLYDG KNMALFEEEM DSNPMVSSLL
NKLANYTNLT QGVKEHEEAD DDEGPAKTKK PVKSPALGTL IGVYLPCLQN ILGVILFLRL
TWIVGTAGIM ESLAIVVMTC SCTMLTAISM SAIATNGVVP AGGSYYMISR SLGPEFGGAV
GLCFYLGTTF AGSMYILGTI EILLTYIVPS AAIFKAEKKE DEAEALLNNM RVYGTCCLTL
MSLVVFVGVK YVNKLALVFL ACVILSILAI YAGVIKTAFE PPDFPICLLG NRTLQNHNFD
QCLKTMEVDN VTVTTKLWSL FCDSPDLNAT CNEYFTLNNV TVIQGIPGLT SGVIRDNIWG
DYGPNGMLVE NKHQVSEPAA DTSQDIYMPY VANDITTFFT LLVGIYFPSV TGIMAGSNRS
GDLRDAQKSI PIGTIMAIAT TTFIYISSVI LFGACIEGVV LRDKFGDSVK GNLVIGILAW
PSPWVIVIGS FFSCCGAGLQ SLTGAPRLLQ AIARDGIVPF LQVFGHGKAN GEPTWALLLT
GGICEIGILI ASLDAVAPIL SMFFLMCYLF VNLACALQTL LRTPNWRPRF KFYHWALSFL
GASLCLSLMF ISSWYYALVA MLIAGCIYKY IEYRGAEKEW GDGINGLSLN AARYALIRLE
EAPPHTKNWR PQILLLLNLD SDHTVKHPRL LSFCTQLKAG KGLTIVGSVL EGTYMTKEAE
VKKAEQNIKS SMTTERTKGF CHVVASSNLR DGFSHLIQTA GLGGMKHNTV LMAWPGTWKQ
SNDPVSWKNF IETVRETTAA HQALLVAKNV DSFPTNADRL GQGTIDVWWV VHDGGLLMLL
PFLLRQHKVW RKCKMRIFTV ANMDDNSIQM KKDLQMFLYH LRLDAEVEVV EMHDSDISAF
TYEKTLVMEQ RSQMLKQMQL SRTEREREIQ SITDSSRSSI RRNNQTGATG SGSGPSRELE
DTQEDEVANT HHLYPQCPCD CSPSPPLRPT PRGHTYTADA GPDRVHMTWT KDKGQGCVGF
SLLFFTVTLV WYRNQSNVRR MHTAVKLNEV VVNKSQGAHL VLLNMPGPPK NRGGDENYME
FLEVLLEGLN RVLLVRGGGR EVITIYS
//
