ID A0A673Y2L8_SALTR Unreviewed; 1023 AA.
AC A0A673Y2L8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 5-like {ECO:0000313|Ensembl:ENSSTUP00000028746.1};
GN Name=LOC115208377 {ECO:0000313|Ensembl:ENSSTUP00000028746.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000028746.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000028746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A673Y2L8; -.
DR Ensembl; ENSSTUT00000030084.1; ENSSTUP00000028746.1; ENSSTUG00000009221.1.
DR GeneTree; ENSGT00940000165387; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..245
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 361..645
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 659..777
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 790..1023
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 899..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 112974 MW; 0CCCB5C66C7CD5AB CRC64;
FPKFPELLHP IMDRFHCRSR HFHPEANPPL SPLQHTAVQP FETRPTNLKR GKKVAAYSPE
FTVPKVCVHF LFPSIQAPAL GTLMGVYLPC IQNIFGVILF LRMTWMVGIG GVIGSFIIVF
IVCIYLLSVA GGSYYMISRS LGPEFGGAVG ICFYLGTTFA GAMYILGSIE LLLIYILPQA
AIFKMEGLEG AEAEAAMLNN MRVYGTIVLS FMATVVFVGV KYVNKLALLF LACVILSILA
VYAGVIKTAI EPPDFPVCML GNRPLISKGF DVCAKTLESG NGTVTTKLWK IFCDTPFLNA
TCDEYFANNN VSFIQGIPGV MSGILKENLF GNYLEKGNLV AKIGIATVEG PDETLTNSNR
YVLADITSFF TLLVGIYFPS VTGIMAGSNR SGDLRDAQKS IPIGTIMAIT TTSLVYMSAV
VLFGACIDGV VLRDKFGEGV NGNLVIGTLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLM
QAISRDGVVP ILRVFGHGKA NGEPTWALLL TACICEIGIL IASLDAVAPI LSMFFLMCYM
FVNLACALQT LLRTPNWRPR FKFYHWALSF LGMSLCLSLM FICSWFYAIV AMVIAGSIYK
YIEFHGAEKE WGDGIRGISL SAARYALMRL DEGPAHTKNW RPQLLVLVST DVEQNVEQPR
LLSLTNQLKA GKGLTIVGTA LAGTYLENHP QAQRAEQSLR KLMETEKVKG FCQVTISSNM
RDATSHLLQA SGLGGLMHNT VLVSWPRNWK QADDHQTWRD FIELVRETTA AHLALLVPKN
IAAFPSNGER FSEGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ
MKKDLTTFLY HLRIDAEVEV VEMHDSDISA YTYEKTLVME QRSQILKQIN LTKTEREREV
QLIHDSTTPT SPVNPATLTQ ATEGGAQTPG SAQVQMTWTE KADGELAKPN QSNVRRMHTA
LRLNGVIVKK SSEAKLVLLN MPGPPKNRAG DENYMEFLEV LTEGLNRVLL VRGGGREVIT
IYS
//
