ID   A0A673YQE7_SALTR        Unreviewed;       968 AA.
AC   A0A673YQE7;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSSTUP00000036926.1};
GN   Name=hip1r {ECO:0000313|Ensembl:ENSSTUP00000036926.1};
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000036926.1, ECO:0000313|Proteomes:UP000472277};
RN   [1] {ECO:0000313|Ensembl:ENSSTUP00000036926.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   AlphaFoldDB; A0A673YQE7; -.
DR   Ensembl; ENSSTUT00000038583.1; ENSSTUP00000036926.1; ENSSTUG00000015539.1.
DR   GeneTree; ENSGT00940000153594; -.
DR   Proteomes; UP000472277; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   CDD; cd17014; ANTH_N_HIP1R; 1.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472277}.
FT   DOMAIN          23..151
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   DOMAIN          729..968
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          532..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          331..397
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   968 AA;  109476 MW;  A45C78045C98B789 CRC64;
     MNSIRQVPSR VKTKRIETNL GAEREHFDKQ QLSSISKAIN SNEAPVKEKH ARRIILGTHR
     EKGAFTFWSY ALGLPLSSNS ILSWKFCHVV HKVLRDGHQN SLQDCMRHHS NIVETGQLWG
     NLHDRYGQLV ALYAKLLCTK MEFHVKHSEI RANLEVTDEV LERVAGTDIN NLNTSIAIST
     LTSGQCRLSP LIQVIQDCSH LYHFTVKLLF KLHACLPADT LQGHRDRFHD QFHSLKTFFN
     KARDMMYFKR LIQIPKLPES PPNFLHAASL AKHARPVVVI PDEEEPEQVD DDDDDPEPLI
     NVSDVTMPSM AVPQVRLIEA VCLLVHRDIQ IENLKRDLEL LRTDLERVKG EAQRYITQLK
     SQINSLEAEL EEQRVQKQRA LVENEQLRME LEATQAESKR SHSLSLAYIA QATEQRYNKL
     REKHTELVSS HAELLRKSAD TVKMLSATQQ TQEEVERTKQ QLAFEVDRIK QDADMKLEEQ
     KFEMEKLKRE FEEKKAEVER VKGTLSMSAL QAEKERLMHS VSEKEAALSS LRHAAQLQQS
     SLQQERERST RELGELQGRL QEKVSQDSTL QQKLLEEQFS LLQGTVSEAE SIIQDAVAKL
     DDPLHIRCTS SPDYLVSRAE ATLGSIDKVK KGHSDYLTNM GDVGGLLRAL TQFSHLAADT
     IINGSATAHM APTDHADRLT ENCRGCATQS LQFLKDLKSK ASLQRADLAS IRIVVQKILR
     LGEELRPKGM DVRQDELGDL VDKEMAATSA AIEEAVRRID EMMNQARKDT SGVKLEVNER
     ILYSCTDLMK VRWLLFYLID LLKRSDRNPN NGAATIKEFY ARNSRWTEGL ISASKAVGWG
     ATQMVESADK VVLHTGKYEE LIVCSHEIAA STAQLVASSK VKADRNSTKL TALQQASRRV
     NEMAANVVAS TKTGQENLED KDTMDFSGMS LIKLKMEEME SQVSHQACVC LFEPVCMSDM
     QTGGDPIL
//