ID   A0A673Z245_SALTR        Unreviewed;       750 AA.
AC   A0A673Z245;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   Name=NCSTN {ECO:0000313|Ensembl:ENSSTUP00000040635.1};
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000040635.1, ECO:0000313|Proteomes:UP000472277};
RN   [1] {ECO:0000313|Ensembl:ENSSTUP00000040635.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A673Z245; -.
DR   Ensembl; ENSSTUT00000042461.1; ENSSTUP00000040635.1; ENSSTUG00000015222.1.
DR   GeneTree; ENSGT00390000014633; -.
DR   InParanoid; A0A673Z245; -.
DR   OMA; ECVYPGV; -.
DR   Proteomes; UP000472277; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        711..731
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          92..265
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   750 AA;  83191 MW;  5C8DD88F861360D8 CRC64;
     MPQGGRLYGA LQIKILPASC VIGCFSIALT SSTYFHLLVL ISMTSSVVSE TRKMDLESSK
     WVIIFLVCGL YKNVSCNSVE QKIYVELNNT VPCVRLLNAT HQIGCQSSIS GDTGVIHVLE
     SESDLEWPLS KGPNPPYMVL LESSLFTRSI MMKMKNESNR VAGVAVVVPN TSPPEFSPHT
     TCPNENTGVY SDNYGPNLAH CNTTVWNPLG NGLSYEEFDF PVFSLKEDNE TEFIKQCYLD
     HNRAVNGSDP QYPLCAMQLF SHMHAVTNTP TCMRRNDINF SINPEMVCDP LGDYNVWGSI
     RPYNDTVFGH KENESVVIAA ARLDSRAFFW EVSTGAEGSI SGFVTLLAAA QALREVTHKA
     PPTRNILFAF FQGETFDYIG SSRMVYDMEN GKFVIDLDNV HSILEIGQVA LHSGTNLFLH
     SDPVSRRNNT VNDEVKNLVN NLQSSTTGLS FLLVEPNVSQ PLPPSSLQRF LRAQPIPGIV
     LADHESAFNN RYYESFYDNA ANLNLTYPSD FSPEEQLEFV TETAKSLTDV ATVVARALYK
     QAEGDKSLVN TIKADPKIVT QMLYGFLVSS NNSWFQAVMA PELKNILKPS APEYYVGVAM
     SSTPTRLVQY LLANLTGAAT NLTQSQCQKP DELPNESRQM YSYLWVQGVV PPNSTQRDSF
     CVRASVRLTK AVSPAFELGE YASKDYSTWT ESRWKFIKAR IFLVASRDLE MLTLGAGVAV
     LFTSLLVTYF ISTKADVLFS STREPASAAY
//