ID A0A673Z8W0_SALTR Unreviewed; 1116 AA.
AC A0A673Z8W0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSSTUP00000043213.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSSTUP00000043213.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000043213.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000043213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A673Z8W0; -.
DR Ensembl; ENSSTUT00000045111.1; ENSSTUP00000043213.1; ENSSTUG00000016910.1.
DR GeneTree; ENSGT00940000158642; -.
DR InParanoid; A0A673Z8W0; -.
DR OMA; HKHMPED; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277}.
FT DOMAIN 50..368
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 606..797
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 826..923
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1000..1097
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 400..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 708..738
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 413..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..480
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 127466 MW; 489A409122B71C2D CRC64;
MGEIEGSYRA IQTPGTRLGA QFNAGISTLE PGQSLSDALG PGGRSPGRGL QLRVQGLDDS
QEFYNLESRA DGQTLLSDVF RRSNLMESDY FGLEFQNMQM SWVWLEPTKL VVKQVKRPMN
TLFRLSVKFF PPDPGQLQEE YTRYLFSLQM KRDLLEGKLS CTENTASLLA SHLLQSEIGD
YDDVADRDFL KLNKLLPNQE RIQERIMELH HRHLGQTPAD SDFQVLEIAR KLEMYGVRFH
PAADREGTKI NLAVAHIGLQ VFQVTSSSTA DTHTPRSTPE NAPEASSLRF HIFVFCLLFS
QGNTKINTFN WSKIRKLSFK RKRFLIKLYP EVHGPHQDTL EFQMVSRDQC KIFWKNCVEH
HSFFRLLDQP QPKSKAILFS RGSSFRYSGR TQKQLVEYVK DSGARRTPYQ RRNSKVRMST
RSLAPDVPKQ TLSFNDSLRA PGSPSSGTGS FHSIQVSSSP LRPEPQIQSP QPPPQSQAQS
SQPPPQRQAQ SPQLPPQQQQ TQLLPPQLAR PSSPPAKEDP HKATGIPPCH HAFSQGSSMD
SPQLSPFSSK SSPLCLSPSF QMSTLSLPGA GQVPSPLQSP ILSEVGTNRL EEEEEEGRRK
RYPTDKAYFI AKEILTTERT YLKDLEVITV WFRSAVIKEN AMPEGLMALL FSNIDPIYEF
HRGFLKEIDQ RLALWEGRSN AHVKGDYQRI GDVMLRNMCA LKEFTSYLQK HDEVLTELEK
ATKRLKKLET VYKEFELQKV CYLPLNTFLL KPIQRLMHYK LILERLCKHY SPDHPDHNNC
REALKEVAEM ATQLQSSLIR LENFQKLSEL QRDLIGIENL TAPGREFIRE GCLYKLTKKG
LQQRMFFLFS DQLLYTSKGV TATNQFKVHG QLPLHGMIVE ESENEWSVPH CFTIYSAQRT
IVVAASSKVE MGKWIEDLNM AIEMAKKSQE KSDLFLDPGL CDRSNRSSDE VSLEQESEDD
MSSSRNSLDK QTHHRANSTM HVCWHRNTSV SMSDHSLAVE NQLSGYLLRK FKNSNGWQKL
WVVFTNFCLF FYKTHQDDFP LASLPLLGYT VSSPGESDSI HKEYVFKLQF KSHVYFFRAE
SEYTFERWME VIKSAASATG RMSLLIPKGP LQMNGN
//