ID A0A673ZBQ6_SALTR Unreviewed; 1134 AA.
AC A0A673ZBQ6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSSTUP00000044217.1};
GN Name=slc12a2 {ECO:0000313|Ensembl:ENSSTUP00000044217.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000044217.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000044217.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A673ZBQ6; -.
DR Ensembl; ENSSTUT00000046159.1; ENSSTUP00000044217.1; ENSSTUG00000017768.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 245..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..182
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 217..724
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 733..1134
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 124105 MW; 9FD53FF013FA799F CRC64;
MSAPSSLPPA QGENPVAENE GLAVDTGLKP AGPTPSSSRF QVDLVAEAAG AADKTLASGD
KDAPAPEGSE PAAGGEEAKG RFRVVNFVDP SGASPPEAVP AEGFQNGDTV MSEGSLHSST
GGQHHYHYDT HTNTYYLRTF GHNTIDAVPN IDFYRQTAAP LGDKLIRPTL SELHDELDKE
PFEDGFANGD ELTPAEEAAA KEASEPKGAV KFGWIKGVLV RCMLNIWGVM LFIRMSWIVG
QAGIVLSCVI VLMATVVTTI TGLSTSAIAT NGFVRGGGAY YLISRSLGPE FGGSIGLIFA
FANAVAVAMY VVGFAETVVE LLVSVDCIMT DEINDIRIVG TITVILLLGI SVAGMEWEAK
AQIFLLVVLI TAIFNYFIGS FIPLQSKESQ GFFGYDSGIM MENMGPDFRG TESFFSVFAI
FFPAATGILA GANISGDLSD PQLAIPRGTL LAILITGIVY LGVAISTGSC IVRDATGNDN
DTHSAQIMAN CTDAACKFGY DFSSCKSDKG LYNCRYGLQN DFQVMSIVSG FGPIITAGIF
SATLSSALAS LVSAPKVFQA LCKDNIYPGL EMFAKGYGKN NEPLRGYILT FCIALAFILI
AQLNVIAPII SNFFLASYAL INFSVFHASL ANSPGWRPSF KYYNMWVSLA GAVLCCVVMF
VINWWAALMT NVIVMGLYIY VSYKKPDVNW GSSTQALTYH QALTHSLHLS SVEDHIKNFR
PQCLVMTGYP NSRPALLHLV HAFTKNVGLM ICGHVRTGSR RPNFKELSND QTRYQRWLMK
NETKAFYTPV FAEDIREGTQ YLLQAAGLGR LRPNTLVIGF KNDWKDGDMM NVETYIQMIH
DAFDYQYGAV VLRLKEGLDV SHISEQDDLL SSQEKTSGMK DVVVSIDMKD SDGDSSKPSS
KATSVQNSPA IQKAQSLIIP QMLNVADQRL LDASQLFKRK QGKGTVDVWW LFDDGGLTLL
IPYLLTNKKK WNDCKIRVFI GGKINRIDHD RRAMATLLSK FRIDFSDINV LGDINTKPKK
ENVTAFEEMI EPYRLKEDDM EQDTAEALKA SEPWRITDNE LELYRAKTNR QIRLNELLKE
HSSTANLIVM SMPLARKGAV SSALYMSWLE TLSKDLPPLL LVRGNHQSVL TFYS
//
