ID   A0A673ZEY2_SALTR        Unreviewed;       457 AA.
AC   A0A673ZEY2;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Rho GTPase-activating protein 8-like {ECO:0000313|Ensembl:ENSSTUP00000045844.1};
GN   Name=ARHGAP8 {ECO:0000313|Ensembl:ENSSTUP00000045844.1};
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000045844.1, ECO:0000313|Proteomes:UP000472277};
RN   [1] {ECO:0000313|Ensembl:ENSSTUP00000045844.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A673ZEY2; -.
DR   Ensembl; ENSSTUT00000047838.1; ENSSTUP00000045844.1; ENSSTUG00000019194.1.
DR   GeneTree; ENSGT00940000160758; -.
DR   InParanoid; A0A673ZEY2; -.
DR   OMA; CITHFES; -.
DR   Proteomes; UP000472277; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR031806; DUF4744.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR   PANTHER; PTHR45808:SF4; RHO GTPASE-ACTIVATING PROTEIN 8; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF15918; DUF4744; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472277}.
FT   DOMAIN          61..200
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          227..430
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
SQ   SEQUENCE   457 AA;  53022 MW;  41285C374CBFCA2E CRC64;
     MTSQYPIMTS QYPIMTSQYP IMTSQYPIMT SQYPIMTSQY PIMTSQYPIM TKCKQVEKCD
     DNYGRKLVIF SSCLMPPSHQ LNHHHLLQYL MYTLDQYVES DYTVVYFHHG LRSNNKPSLH
     WLRNAYREFD RKYKKNLKAL YVVHPTNFIR IIWNIFQPLI SHKFGKKLTY VNYLAELRDH
     LSWDQLIIPP DVLRHDERLR AAQKGGPHPS SKTPPPRPPL PTQQFGVSLQ YIVEKNQGVM
     IPPVMSQTVS YLKDKGLQTE GIFRRSARVQ LIKDVQKLYN QGKPVVFEQY GDIHVPAVIL
     KTFLRELPEP LLTFPLYHQI QDIVPSFTRP LKPYLSELKR EPQHSSLRVT TCKSILESLP
     EHNYMVLKYL LCFLNMVSQQ SIVNKMSPSN LACVFGVNLS WPSQGSVSLT SLTPLNIFTE
     ILIEHYHTVF SSRCPQAEPR HLATNPTKQT CCDCLLG
//