ID A0A673ZF61_SALTR Unreviewed; 542 AA.
AC A0A673ZF61;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
GN Name=TYR {ECO:0000313|Ensembl:ENSSTUP00000045478.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000045478.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000045478.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SUBCELLULAR LOCATION: Melanosome membrane
CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004573}.
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR AlphaFoldDB; A0A673ZF61; -.
DR Ensembl; ENSSTUT00000047461.1; ENSSTUP00000045478.1; ENSSTUG00000019139.1.
DR GeneTree; ENSGT00940000155336; -.
DR InParanoid; A0A673ZF61; -.
DR OMA; MEAEDYQ; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..542
FT /note="Tyrosinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025410336"
FT TRANSMEM 476..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..222
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 386..397
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 542 AA; 61546 MW; 78B043A6AC9F9D61 CRC64;
MRLLLLHGVF FLQCVWLSQQ QFPRLCATTE ALLSKECCPV WDGDGSACGA SSGRGFCRDV
EVSDLPNGLN YPFSGLDDRE RWPLVFYNRT CQCASNYMGF NCGECQFGLF GTNCGERRES
VRRNVFHLSA AERRKLISYL NLAKHTVSQD YVIATGTYRE MNNGSTPLFS DVSTYDVFVW
MHYYVSRNAL LGGPGNVWTD VDFAHWAPAF LPWHRAYLLH WERDIRKLTG DFEFSIPYWD
WRDAQGCDVC TDDLMGARSP RDPNLISPAS VFSSWKVMCS RAEDYSVRGV LCDGSDEGPL
LRNPGNHNRN LVPRLPTAAE VEFTVSLRDY DTGAMDRSAN FSFRNTMEGF GNPQTGLGNS
RVMGMHASLH IFMNGSMSSV QGSANDPIFL LHHAYVDSIY EQWLRRHAPE QTQYPEFNAP
IGHNRQYHMV PFIPLHRNIE YFTSSKDLGY EYSYMLDSDQ RISEVLSPYL ELMMEAWPWL
LGALVLGALV AMTVAAVAVT MTRVCWGAWP WQRGEKGSAF HLPEREPLII SSDSDTPNYH
TV
//
