ID A0A674A5I4_SALTR Unreviewed; 933 AA.
AC A0A674A5I4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000313|Ensembl:ENSSTUP00000054157.1};
GN Name=LOC115203249 {ECO:0000313|Ensembl:ENSSTUP00000054157.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000054157.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000054157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A674A5I4; -.
DR Ensembl; ENSSTUT00000056636.1; ENSSTUP00000054157.1; ENSSTUG00000022650.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..50
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 51..92
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 93..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 745..857
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 333..343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 933 AA; 104385 MW; 3337A1FE534BD9F5 CRC64;
MKSYVLSYLL TYTCAEGSDG CHIDAICQNT QASYKCTCKV GFKGDGKHCE DIDECDIEYN
GGCVHECNNI PGNYRCTCHD GFSLAHDGHN CLDVDECVFN NGGCQHTCVN TMGSYECSCK
EGFFLSDNQH TCIHRSVEGL SCMNKEHGCA HICKETPKGG VACECRPGFE LAKNQRGCIL
TCNHGNGGCQ HTCEDMEQGP ICRCHVRYTL HPDGRSCVER DETTTESSDH NATSFTEVDK
RVKRRLLMEN CAVNNGGCDS TCKDTSTGVR CSCPVGFTLQ PDGKTCKDIN ECELHNGGCD
HFCRNTIGSF ECNCWKGFKL LTDEHSCQDI DECYFERTCG HTCVNSPGGF ECVCNKGYSL
YGLAHCGDIN ECSVNNGGCE QGCENTRGGF ECHCHPGYKL HWNKKDCIGK TPPSKPTLNC
SRQEGSDRCY LTCQSQVHIT SGELSVTTTT TIGLHPKWHP IPFILHNFLC VSVYFSTGMC
VGFCLSVYCG LIVLRGQFWY LVFLSAESCD LGCVRRRSEK KLKKTIRTLR KSIHREQFHL
HFAGSNYELA KRLARPVDLP EHCGKGQVLV DRKCVSCTVG TYYDRDQGRC VLCPAGMYQD
EEENNSCEAC PGPEVRGSPR SVGVRNISEC GVQCPPGQFS HDGFIPCLPC PMGTYQPEVG
RTSCFHCGGN LVTKHNGAVS FQDCETKVQC SPGHHYNTST HRCIRCPMGT YQMEFGQNYC
ISCPGNTTTD FDGSTNIMQC KNRHCGGEMG DFTGYIESPN YPGNYPANIE CTWTINPPPK
RRILIVVPEI FLPIEDECGD YLVMRKSSLS NSVTTYETCQ TYERPIAFTS RSKRLWIQFK
SNEGNSGKGF QVPYVTYDED YQELIEDIVR DGRLYASENH QEILKDKKLM KALFDVLAHP
QNFFNYTAQE SREMFPKSFI RFLRSKVLRF LRP
//
