ID A0A674A7I8_SALTR Unreviewed; 1012 AA.
AC A0A674A7I8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Solute carrier family 12 member 1-like {ECO:0000313|Ensembl:ENSSTUP00000055379.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSSTUP00000055379.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000055379.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000055379.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A674A7I8; -.
DR Ensembl; ENSSTUT00000057928.1; ENSSTUP00000055379.1; ENSSTUG00000021248.1.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..121
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 153..659
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 669..796
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 805..1012
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 38..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 111017 MW; DA63D8404921466F CRC64;
MAESQAEPTN LSLYDRSIEA SRCEEPVFTA SLMENDAYDR IGDEPPNYEE TSFSGGTTSN
GNGTGNGEHR AVRPSVVSAF GHDTLDRVPN IDFYRNAGSV SGNRAVRPSL QELHDVFQKV
SVEGSDGTPS DDVESVIPLD NKDGTVRFGW IKGVLVRCML NIWGVMLFIR LSWVFGQAGW
GLGIVVIALS CVVTTVTGLS MSAICTNGVV RGGGAYYLIS RSLGPEFGGS IGLIFAFANA
VAVAMYVVGF AETVVDLLKE NDAIMIDELN DIRIIGCISV VLLLGISVAG MEWEAKAQIG
LLIILLIAIA NVFVGTGIPA STDKKSKGFF NYDAKIFMEN LPPDFRNGET FFSVFAIFFP
AATGILAGAN ISGDLKDPQD ALPKGTLLAI LITGVTYLGV ALCVSATVVR DATGNINDTI
ATGMEMLCNG TNTAACEQGW NFSSCDVNSC KFGSMNNFQV MTMVSGFGPL ITAGTFSATL
SSALASLVSA PKVFQALCKD NIYTALKFFA KGHGKNNEPI RGYVLTFIIA VAFIIIADLN
VIAPIISNFF LASYALINFS CFHASYAKSP GWRPAYRYYN MWLSLFGAVL CCGVMFVINW
WAALLTYAIE IFLYVYVTVK KPNVNWGSST QAVTFVSAVN NALSLTGVED HVKNFRPQCM
VLTGAPKNRP ALLDLAHCFT KNYGLCLTYV NAGMEKNQMW LNKKKRKAFY AAVACDSFRQ
GTEILLQASG LGRLKPNILM MGFKKDWRTA DTAGVQSYVG ILHDAFDFEY GTVVLRMNQG
LDISHIIKAQ ASVTTPQSPQ VVVVNERLVS TSTQFQRKQG KGTIDVWWMF DDGGLTLLLP
YILTTRKKFK DCKMRIFIAG QPGRVEQDRH EMKSLLEKFR IKYADIHVID DITQNPNSNS
WKMFEDMIEP FRLHEGSKST TLAEALRKDS PWKISDAELD TFEEKTNLQV RLNELLQENS
RAANLIIVSM PIARLGSVSD HLYMAWLDIL TKNLPPTMLI RGNHKSVLTF YS
//
