ID A0A674A7T9_SALTR Unreviewed; 926 AA.
AC A0A674A7T9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Proto-oncogene DBL-like {ECO:0000313|Ensembl:ENSSTUP00000055479.1};
GN Name=LOC115172813 {ECO:0000313|Ensembl:ENSSTUP00000055479.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000055479.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000055479.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A674A7T9; -.
DR Ensembl; ENSSTUT00000058037.1; ENSSTUP00000055479.1; ENSSTUG00000023385.1.
DR GeneTree; ENSGT00940000156974; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000472277}.
FT DOMAIN 1..93
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 507..688
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 706..822
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 105292 MW; CAC9AF35A3FA95E2 CRC64;
MAVNTMAESY QRRGLHRTRK SPASFPGNLH LVLVLRPTSF FQRTVTDLGF RFSQEDFMLK
MPVVMLSSVT DLLRYIDENQ LTSEFGGTLD YCHSDWIVLR TAIESFAVTV KDIAQMLQGF
GTELAETKLP DEGTAIMRLL STHTDKYRKL KEAIRSVSKE GRHLLASLEA SGREEDSLWD
VRLDWETVQR LLAQLRGMES AFDGFFEKHH LKLQQYLQLL RYEHRFKEME LSLERLASQE
REVSSSGETL TQTEQTLRDL DSLEAHAQEE MGRAQIIILH GHQLAASHHY AMALIVQRGN
ELRHHCDTLS NALRVKRAHL SQAHRLLLCL GQAQSWCDDG AYLLAQQLVG KFQSKEGAQA
ALKDIDRFLE GAPSLLSSGH NLLAVEFESV VTPEIQVQIG KTFEKHTVVQ EMIHNRQVCL
RKLADKHVRP IQLVAPRAES PPRSKSPLFS PKHGVDSLKF SFDLSLPGKR TSRKSPASRK
IEVMHDYQEN RSSLRSSLEG EDSPDLLKRH VMRELIETER VYVEELLSVL LGYRGEMENP
ALAGLLPPTL RSKRNVLFGN MPEIYNFHSR VFLHDLEGCL ETPEGVGACF LERKENFKVY
ACYCQNKPRS ESLWRQYSDC AFFQECQKKL EHKLGLDSYL LKPVQRLTKY QLLLKELLKY
SAGGCEGTSE LQAALAAMLH LLKSVNDSMH QIAITGYQGE LCDLGRVLMQ GSFSVWISHK
KGPTRVKELA RFQPTQRHLF LYERALLFCK RREEHGEGAD KTPSYSFKHC LKMSAVGITE
NVKGDVKKFE IWYSGREEVY VVQAPTVEVK TAWLGELRRI LTNQQKLLKD ERCVDIQMPD
HIRRSPPVSE SKQQRASFSS EDTVREEQYR PTVPLPKSPA QPTQLARHAS LNGHLSGSGG
VGWRSGPHSP VRHRGGGHCS AGSRQI
//
