ID A0A674A976_SALTR Unreviewed; 812 AA.
AC A0A674A976;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Proto-oncogene DBL-like {ECO:0000313|Ensembl:ENSSTUP00000055467.1};
GN Name=LOC115172813 {ECO:0000313|Ensembl:ENSSTUP00000055467.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000055467.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000055467.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A674A976; -.
DR Ensembl; ENSSTUT00000058024.1; ENSSTUP00000055467.1; ENSSTUG00000023385.1.
DR GeneTree; ENSGT00940000156974; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000472277}.
FT DOMAIN 51..182
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 481..653
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 671..787
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 440..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 92375 MW; 9A7B1AA4708EAB1A CRC64;
MECYHSLLQA GSQLENTLQQ VSVSMSMKEV DGYIEKQVAY LSGGRGEDSS VIVTLPEYSA
FSDIPEESLA KVLTYLTLIP RARQPGVKFI IILDRRLDTW TSIKTALARI AASFPGNLHL
VLVLRPTSFF QRTVTDLGFR FSQEDFMLKM PVVMLSSVTD LLRYIDENQL TSEFGGTLDY
CHSDWIVLRT AIESFAVTVK DIAQMLQGFG TELAETKLPD EGTAIMRLLS THTDKLLAQL
RGMESAFDGF FEKHHLKLQQ YLQLLRYEHR FKEVRLINCI EEMGRAQIII LHGHQLAASH
HYAMALIVQR GNELRHHCDT LSNALRVKRA HLSQAHRLLL CLGQAQSWCD DGAYLLAQQL
VGKFQSKEGA QAALKDIDRF LEGAPSLLSS GHNLLAVEFE SVVTPEIQVQ HQKHTVVQEM
IHNRQVCLRK LADKHVRPIQ LVAPRAESPP RSKSPLFSPK HGKRRSSLRS SLEGEDSPDL
LKRHVMRELI ETERVYVEEL LSVLLGYRGE MENPALAGLL PPTLRSKRNV LFGNMPEIYN
FHTLHGWCVI GNVCVYFQKE NFKVYACYCQ NKPRSESLWR QYSDCAFFQE CQKKLEHKLG
LDSYLLKPVQ RLTKYQLLLK ELLKYSAGGC EGTSELQAAL AAMLHLLKSV NDSMHQIAIT
GYQGELCDLG RVLMQGSFSV WISHKKGPTR VKELARFQPT QRHLFLYERA LLFCKRREEH
GEGADKTPSY SFKHCLKMSA VGITENVKGD VKKFEIWYSG REEVYVVQAP TVEVKTAWLG
ELRRILTNQQ KLLKGLDVAH ITLQSALRKE LV
//
