ID A0A674A9S3_SALTR Unreviewed; 1017 AA.
AC A0A674A9S3;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Solute carrier family 12 member 1-like {ECO:0000313|Ensembl:ENSSTUP00000056018.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSSTUP00000056018.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000056018.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000056018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A674A9S3; -.
DR Ensembl; ENSSTUT00000058598.1; ENSSTUP00000056018.1; ENSSTUG00000021248.1.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 137..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..106
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 136..642
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 652..795
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 805..1017
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 22..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 111286 MW; 5D21D4F6109B623D CRC64;
PTLVSSRCEE PVFTASLMEN DAYDRIGDEP PNYEETSFSG GTTSNGNGTG NGEHRAVRPS
VVSAFGHDTL DRVPNIDFYR NAGSVSGNRA VRPSLQELHD VFQKVSGSDG TPSDDVESVI
PLDNKDGTVR FGWIKGVLVR CMLNIWGVML FIRLSWVFGQ AGWGLGIVVI ALSCVVTTVT
GLSMSAICTN GVVRGGGAYY LISRSLGPEF GGSIGLIFAF ANAVAVAMYV VGFAETVVDL
LKENDAIMID ELNDIRIIGC ISVVLLLGIS VAGMEWEAKA QIGLLIILLI AIANVFVGTG
IPASTDKKSK GFFNYDAKIF MENLPPDFRN GETFFSVFAI FFPAATGILA GANISGDLKD
PQDALPKGTL LAILITGVTY LGVALCVSAT VVRDATGNIN DTIATGMEML CNGTNTAACE
QGWNFSSCDV NSCKFGSMNN FQVMTMVSGF GPLITAGTFS ATLSSALASL VSAPKVFQAL
CKDNIYTALK FFAKGHGKNN EPIRGYVLTF IIAVAFIIIA DLNVIAPIIS NFFLASYALI
NFSCFHASYA KSPGWRPAYR YYNMWLSLFG AVLCCGVMFV INWWAALLTY AIEIFLYVYV
TVKKPNVNWG SSTQAVTFVS AVNNALSLTG VEDHVKNFRP QCMVLTGAPK NRPALLDLAH
CFTKNYGLCL TCEVFVGPRT ETLTDVNAGM EKNQMWLNKK KRKAFYAAVA CDSFRQGTEI
LLQASGLGRL KPNILMMGFK KDWRTADTAG VQSYVGILDA FDFEYGTVVL RMNQGLDISH
IIKAQGESSQ NTPASASVTT PQSPQVVVVN ERLVSTSTQF QRKQGKGTID VWWMFDDGGL
TLLLPYILTT RKKFKDCKMR IFIAGQPGRV EQDRHEMKSL LEKFRIKYAD IHVIDDITQN
PNSNSWKMFE DMIEPFRLHE GSKSTTLAEA LRKDSPWKIS DAELDTFEEK TNLQVRLNEL
LQENSRAANL IIVSMPIARL GSVSDHLYMA WLDILTKNLP PTMLIRGNHK SVLTFYS
//
