ID   A0A674AE63_SALTR        Unreviewed;      1228 AA.
AC   A0A674AE63;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=VPS10 domain-containing receptor SorCS1-like {ECO:0000313|Ensembl:ENSSTUP00000057355.1};
GN   Name=LOC115147218 {ECO:0000313|Ensembl:ENSSTUP00000057355.1};
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000057355.1, ECO:0000313|Proteomes:UP000472277};
RN   [1] {ECO:0000313|Ensembl:ENSSTUP00000057355.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A674AE63; -.
DR   Ensembl; ENSSTUT00000060145.1; ENSSTUP00000057355.1; ENSSTUG00000023930.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   Proteomes; UP000472277; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1189..1209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          906..963
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          178..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1228 AA;  137545 MW;  F83147B903104FE0 CRC64;
     MERVVRLCPI WHNNVFWFML LIIIYFFLAA KSELTCRSCQ PGDKGRIKEL LFKTDTREFA
     TGYGEEVIGN GDGATASRSL NSASAETQQL DCAVGSDECI QGKYIYSRRK RNTDMLFRSK
     NALLDGGMHY GGGKQRKFTP RGEYKVSNLK MNLHAGNTDV GKTRADLIPD ISHKHRVRRN
     SPRANIGDNK VKFSGSPKRR ETLPLSYSRE GITSPAGRSR VTRSELRWSN EDRRAASSRQ
     DELKLTSSTF ALTGDSAHNQ AMVHWSGQNS SVILMLTKLF DFNLNSVTES SLWRSTDYGT
     TYQKLNEKVG TKTILSYLYV SPNNKRKIML LTDPEVESSL LISSDEGATY QKYRLSFYIL
     SLLFHPEQED WILAYSHDQK LYSSVEFGRR WQLVHERVAP NRFYWSKTGL DKEPGLIHLE
     TIISEGQALY VTCKLQNCTE ANKGKPFPGY IDPNSLVVQD EYVFVQVSTG GRPIYYVSAK
     REVFTPMKLP KYTLPKDLHV ISTDENRVVA AVQEWNQNDT YNLYVSENGG VFYTLALENV
     VSSMGHEGNV MIDLYEVAGI KGMFLANKKM DNVVKTYITY NRGRDWRLLQ APTADLRGNS
     IRCELPYCSL HLHLHVSANP YTSGNIESKD SAPGIIVASG SIGAELTTSN VSMFITSDAG
     NTWRQIFDEE YSVLYLDQGG ALVAIRHTPL PIRHLWMSFD EGRQWNKYSF TMSPLFVDGL
     LGEPGEETLI MTIFGHVSHR SEWQLVKIDF RSIFNRRCTE GDYQTWHLHN RGEPCIMGVK
     RIYRKLKPIA RCVMGKTYSV TMTSAPCDCT EADFECDYGY ERRSDGKCTP AFWFLPSSMS
     RSCTTGTTFI NSTGYRKVVS NNCTAGVIAE YTARRQHCPT QAPKGLHLVT SEGKLTATLG
     TNVTFLVFLE EGDGARTSIM VDFGDGHALT YSNVSSIEDG VKHVYKAVGI YRVTATGENS
     LGSESVVLYL HVTCQLEYIH LSAPFVAVKS KEVNLTAVLW PSQVGTVTYI WWFGNNTEPI
     ITLEGSVACT FSQEGVNTVT VQVSAGNAIL QDRKTIAVHE YSRSHLLAFS SNLDDHNPDV
     AEWRLDVSRV IKNSMVKATG VSPEQLLVTV LPGLPTAAEV FLLPDKELTE GKPEKNSAHL
     DQLSEILLSA LNQNLVQFTL RPGVQVTVYA AHLSAAPLVD TSENHSGSAM LMLLSVVVLG
     LAIFVVYKFK RSQASTSMRR CRTKKNKK
//