ID A0A674B0V7_SALTR Unreviewed; 810 AA.
AC A0A674B0V7;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like {ECO:0000313|Ensembl:ENSSTUP00000064687.1};
GN Name=ENPP2 {ECO:0000313|Ensembl:ENSSTUP00000064687.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000064687.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000064687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00010594}.
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DR AlphaFoldDB; A0A674B0V7; -.
DR Ensembl; ENSSTUT00000068422.1; ENSSTUP00000064687.1; ENSSTUG00000024922.1.
DR GeneTree; ENSGT00940000155778; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF127; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 2-LIKE; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 2.
DR Pfam; PF01033; Somatomedin_B; 2.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..810
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025663481"
FT DOMAIN 42..85
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 86..130
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 810 AA; 91292 MW; 3747B6DCB4385234 CRC64;
SFRMTSISHS QAVVLFALLT GSSVSVAYVF QATISDSLWV SSAGSCKGRC FELEEALPPG
CRCDNLCKTY YSCCSDFDEH CLKTAGGFEC SEDRCGETRN DEHACHCSED CLEKGDCCTN
YKALCKGDTK WVDGECKDIT GPECPAGFIR PPLIMLSVDG FRASYMKKGK AVIPNMEKLR
TCGTHAPYMR PVYPSKTFPN LYTLATGLYP ESHGIVGNSM HDPVFDANFH LRGREKLNHR
WWGGQPVSRR ILTILRWLSL PDDERLDIHP LCSFHININL CQPHFHQFLD NPLREIDNVI
GQLMNGLKQM NLHRCVNIIV VGDHGMEEAH CDRTEFLSTY PVNVDEINLI PGSLGRIRAR
DPKSTTCELH STCKMPTQHF KPYLKQHLPK RLHYANNRRI EAVHLLMERK WHVAWKVPEN
RRHPGRCGFF GDHGFDNKIT SMRTIFLGYG PSFMFQTKVA EFENIELYNV MCDLLGLVPA
PNNGTHGSLN NMLKAPPFTP IMPEEVTAPT TSDTTSATTY DLGCSCDNEV NLHCKGFKHS
THLPFGRPAV LFQTTYSLLL HSDFISGYSQ ELSMPLWTSF TVPKQEEVTS LPEPEPVSEC
VRADLRVPPE HSQACTTYSE DTDVSYGFLY PPELALSPES KYDASLITNT VPMYPAFKKV
WSYLQGTLLK RYAEENNGIN VVTGPIFDNN YDGLRDTTVK IKEYAAVSAP VPTHYYVVIT
SCQDVNQTAG VCDGPLNVFS FLLPHRSDND ESCKSSEDES QWVEELLKLH TARVRDVEIL
TGLDLYRSTT LNYTQTLSLK TYLHTFESDT
//
