ID A0A674DMA4_SALTR Unreviewed; 1010 AA.
AC A0A674DMA4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSSTUP00000096684.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSSTUP00000096684.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000096684.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000096684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A674DMA4; -.
DR Ensembl; ENSSTUT00000103842.1; ENSSTUP00000096684.1; ENSSTUG00000039578.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..200
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 318..599
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 613..728
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 729..872
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 938..1010
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1010 AA; 112513 MW; 61F026F7ED21B1F4 CRC64;
MKLDKTPQSR LYNIVLYASP QMGTFIGVYL PCMQNILGVI LFLRLTWIVG TAGILESFAI
VVMCCTCTML TAISMSAIAT NGVVPAGGSY YMISRSLGPE FGGAVGLCFY LGTTFAGSMY
ILGTIEILLT YIVPNAAVFV AEKKEGEAEA MLNNMRVYGT CCLALMALVV FVGVKYVNKL
ALVFLACVVL SIMAIYAGVI KTVIEPPDFP ICLLGNRSLQ NHNFEKCVKT EVIKNVTYTT
KLWELFCDSR HLNATCDEYF TLNNVTEIQG IPGLLSGVIK DNMWGDYGPS GMLVERKRQS
SVPAQDNSRD IYMPYVFNDI STFFTLLVGI YFPSVTGIMA GSNRSGDLRD AQRSIPFGTI
LAIATTSFIY MTCVVLFGAC IEGVVLRDKF GDSVKKNLVI GTLAWPSPWV IVIGSFFSCC
GAGLQSLTGA PRLLQAIARD GIVPFLQVFG HGKANGEPTW ALLMTAGICE IGILIASLDA
VAPILSMFFL MCYLFVNLAC AVQTLLRTPN WRPRFKFYHW TLSFLGMSLC VSLMFISSWY
YALVAMSIAG CIYKYIEYRG AEKEWGDGIR GLSLNAARYA LIRLEEVQPH TKNWRPQLLV
LLKLDSDLGV KHPRLLSFTT QLKAGKGLTI VSSVLEGTYM TLGAEAKSAE QNVKSAMHAE
RTKGFCHVVV SSNLRDGFSH LIQSAGLGGM KHNAVLMAWP RGWKQAEDSY PWKNFIETVR
ETTSAHQALL VAKNIDKFPS NQDRLGEGTI DVWWIVHDGG LLMLLPFLLR QHKVWRKCKM
RIFTVAQMDD NSIQMKKDLQ MFLYHLRLNA VVEVVEMHDS DIAAFTYEKT LVMEQRSQML
KQMQLSRNER EREIQSITDE SRISIKRKNK TSVVIPQAQL ITKLGTKSHG NLNDNATATP
DHRVHMTWTK DKLITERNRN RSEPNVGVKD LFNMKPNQSN VRRMHTAVKL NEVVVNKSQG
AQLVLLNMPG PPKNKGGDEN YMEFLEVLMD GLDRVLLVRG GGREVITIYS
//
