ID A0A674DP53_SALTR Unreviewed; 973 AA.
AC A0A674DP53;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=VPS10 domain-containing receptor SorCS1-like {ECO:0000313|Ensembl:ENSSTUP00000097640.1};
GN Name=LOC115178059 {ECO:0000313|Ensembl:ENSSTUP00000097640.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000097640.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000097640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A674DP53; -.
DR Ensembl; ENSSTUT00000104844.1; ENSSTUP00000097640.1; ENSSTUG00000042977.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 910..928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 632..689
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 973 AA; 109365 MW; 68ADA800C4128EE8 CRC64;
MLTKLFDFNL NSVTESSLWR STDYGTTYQK LNEKVGAKTI LSYLYVSPNN KRKIMLLTDL
EVESSLLISS DEGATYQKYR LSFYILSLLF HPEQEDWILA YSHDQKLYSS VEFGRRWQLV
HERVAPNRFY WSKTGLDKEP GLIHLETIIS EGQALYVTCK LQNCTEANKG KPFPGYIDPN
SLVVQDEYVF VQVSTGGRPI YYVSAKREVF TPMKLPKYTL PKDLHVISTD ENRVVAAVQE
WNQNDTYNLY VSETGGVFYT LALENVVSSM GHEGNVMIDL YEVAGIKGMF LANKKMDNVV
KTYITYNRGR DWRLLQAPAA DLRGNSIRCE LPYCSLHLHL HVSANPYTSG NIESKDSAPG
IIVASGSIGA ELTTSNVSMF ITSDAGNTWR QIFDEEYSVL YLDQGGALVA IRHTPLPIRH
LWMSFDEGRQ WNKYSFTMSP LFVDGLLGEP GEETLIMTIF GHVSHRSEWQ LVKIDFRSIF
NRRCTEGDYQ TWHLHNRGEP CIMGVKRIYR KLKPIARCVM GKTYSVTMTS EPCDCTEADF
ECDYGYDRRS DGKCTPAFWF LPSSMSRSCT TGTTFINSTG YRKVVSNNCT AGVIAEYTAR
RQHCPTQAPK GLHLVTSEGK LTATLGTNVT FLVFLEEGDG ARTSIMVDFG DGHALTYSNV
SSIENGVKHV YKAVGIYRVT ATAENSLGSE SVVLYLHVTC QLEYIHLSAP FVAVKSKEVN
LTAVLWPSQV GTVTYIWWFG NNTEPIITLE GSVACTFSRE GVNTVTVQVS AGNAILQDRK
TIAVHEYFRS HLLAFSSNLD DHNPDVAEWR LDISRVIKNS MVKATGVTPE RLLVTVLPGL
PTAAEFFLLP DKELTEGKPE KNSLSEILLS ALNQNLVQFT LRPGVQVTVY AAHLSAAPLV
DTSENHSGSA MLMLLSVVVL GLAIFVVYKF KRYSFQGRNG LSLNFLRILL SRHFLCPQMK
CQSAFRHYRY LAL
//
