ID A0A674E8M1_SALTR Unreviewed; 1042 AA.
AC A0A674E8M1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 4-like {ECO:0000313|Ensembl:ENSSTUP00000104166.1};
GN Name=SLC12A4 {ECO:0000313|Ensembl:ENSSTUP00000104166.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000104166.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000104166.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A674E8M1; -.
DR Ensembl; ENSSTUT00000111679.1; ENSSTUP00000104166.1; ENSSTUG00000045134.1.
DR GeneTree; ENSGT00940000157672; -.
DR Proteomes; UP000472277; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 159..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..261
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 379..651
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 665..783
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 796..1042
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 58..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 116103 MW; 2365EA181C554483 CRC64;
GHGNHKEDSP FLSSADADRK TDFYDRNLAL FEEELDIRPK VSSLLSRLVN YTNITQGARE
HEEAENTETS RRKAPKSPNM GTLMGVYLPC LQNIFGVILF LRLTWIVGTA GIVQSFLIVL
MCCSCTMLTA ISMSAIATNG VVPAGGAYFM ISRSLGAEFG GAVGICFYLG TTFAAAMYIL
GAIEIFLKYL VPQAAIFHAS DHHGGDSAIL NNMRVYGTIC LSLMAVVVFV GVKYVNKLAS
LFLACVIISI VSIYAGAIKS IFQPPDFSIC MLGNRTLVRD QFDVCSKTVL EGNVTVPSQL
WRNFCSSGNM SSPQCDDYFN QNNVTEIQGI PGLASGIIRD NMWGDYLEKG QILEKAGLPS
VDVHGAVESF GLYVSADIAT SFTLLVGIFF PSATGIMAGS NRSGDLKDAQ KSIPIGTILA
ITTTTLVCIL SWSPCPLLSC RFGDAVSKNL VVGTLSWPSP WVIVIGSFFS TVGAGLQSLT
GAPRLLQAIA KDNIIPFLRV FGHGKANGEP TWALLLTGLI AELGILIASL DMVAPILSMF
FLMCYLFVNL ACAVQTLLRT PNWRPRFKYY HWALSFLGMS MCLALMFISS WYYAIVAMCI
AGMIYKYIEY QGAEKEWGDG IRGLSLSAAR YSLLRLEHGP PHTKNWRPQV LVLLKLDEDL
HVKYPRLLTF VSQLKAGKGL TIVGSVIQGQ FLDSYGETQA SEQAVKNMME IERVKGFCQV
VVASKVREGI AHLIQSCGLG GMKHNTVVMG WPYGWRQSED PRAWKTFINT VRCTTAAHLA
LMVPKNISFY PSNHERFTDG TIDVWWIVHD GGMLMLLPFL LKQHKVWRKC KMRIFTVAQM
DDNSIQMKKD LATFLYQLRI EAEVEVVEMH DSDISAYTYE RTLMMEQRSQ MLRQMRLSSA
EREREAQLVK DRHSLIRMGS LYSDEEEEVV EPVADKIQMT WTKEKYEAER RNRNNAPENF
RELMSLKPDQ SNVRRMHTAV KLNEVIVNKS HDARLVLLNM PGPPRNTDGD ENYMEFLEVL
TEGLERVLLV RGGGREVITI YS
//
